AI Article Synopsis
- A new chiral catalyst system, using (t)Bu-quinolineoxazoline and Pd(II), has been created for efficient enantioselective oxidative cascade cyclization of disubstituted olefins.
- This system demonstrates high yields and impressive selectivity, achieving enantioselectivities up to 98% and diastereoselectivities exceeding 24:1.
- Researchers also introduced a transition-state model to explain the strong control over stereochemistry achieved by this catalyst.
Article Abstract
An air-stable and structurally tunable chiral (t)Bu-quinolineoxazoline/Pd(II) catalyst system has been developed for the enantioselective oxidative cascade cyclization of a variety of disubstituted olefinic substrates, with the apparent advantages of good yields and excellent enantioselectivities (up to 98% ee) and diastereoselectivities (dr >24:1). A transition-state model has also been proposed to account for the excellent stereocontrol.
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| http://dx.doi.org/10.1021/ol902348t | DOI Listing |
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