Stress-protective and stress-potentiating effects of antibodies to glutamate and gamma-aminobutyric acid after intranasal administration in C57Bl/6 mice.

We studied the effects of antibodies to glutamate and GABA administered intranasally 1 h before and immediately after stress on the development of stress response in C57Bl/6 mice. Antibodies to glutamate administered 1 h before stress prevented the development of the stress-reaction judging from behavioral parameters in the open field test and hyperalgesia test, while antibodies to GABA potentiated the severity of stress-induced behavioral disorders: total behavioral activity in the open field decreased significantly. When administered after stress, antibodies to glutamate did not reduce, but exacerbated stress reaction; antibodies to GABA also exhibited a stress-potentiating effect.