The effects of melafen (plant growth stimulant) on membrane structure and functions of animal cells were studied. The process of signal transduction from cell surface to intracellular structures and conformation changes in membranes in the presence of this substance were studied by light scatter and differential scanning microcalorimetry. Melafen in a wide range of concentrations (10(-13)-10(-3) M) inhibited Ca(2+) signal system involved in the function of Ca(2+)-dependent K(+) and Cl(-) channels in Ehrlich ascitic carcinoma cells. Being a hydrophilic substance, melafen had little effect on the lipid phase of artificial membranes, but impaired the function state of transformed cell. The importance of studies of transformed cells causes no doubt because of increasing incidence of diseases associated with uncontrolled cell division.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-009-0618-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Leaves Extracts Inhibit the Development of Ascitic and Solid Ehrlich Tumors.
Pharmaceuticals (Basel)
December 2024
Post Graduate Program in Structural and Functional Biology, Paulista School of Medicine (UNIFESP-EPM), Federal University of São Paulo, São Paulo 04023-062, SP, Brazil.
is traditionally known for its medicinal properties. Objectives: Here, we investigated the effects of crude extract (CE) and ethyl acetate fraction (EAF) obtained from leaves on the ascitic (EA) and solid (ES) forms of Ehrlich tumors. : Induced and uninduced BALB/c mice were treated intramuscularly, for 7 or 14 days, with saline solution or CE and EAF, both at a 10% concentration, based on in vitro cytotoxicity assessment.
View Article and Find Full Text PDFUnveiling the potential anticancer activity of Spirulina maxima extract-nanoemulsion through in vitro and in vivo studies.
Sci Rep
January 2025
Medical Biochemistry Department, National Research Centre, Giza, 12622, Egypt.
Being the second leading cause of death globally, cancer has been a long-standing and rapidly evolving focus of biomedical research and practice in the world. Recently, there has been growing interest in cyanobacteria. This focus is particularly evident in developing innovative anticancer treatments to reduce reliance on traditional chemotherapy.
View Article and Find Full Text PDFRhodium complex [RhLI]I: a novel anticancer agent inducing tumor inhibition and apoptosis.
Discov Oncol
December 2024
Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh.
Numerous chemotherapeutic agents are currently employed in cancer treatment, but many are associated with significant side effects. This study aims to identify a novel anticancer drug that minimizes or eliminates these adverse effects. The anticancer activity of the Rhodium (III) complex cis-[RhLI]I was evaluated through both in vivo and in vitro functional assays.
View Article and Find Full Text PDFMolecular docking and / studies of a novel thiadiazole Schiff base as a hepatoprotective drug against angiogenesis induced by breast cancer.
RSC Adv
December 2024
Department of Pharmaceutics, Faculty of Pharmacy, Delta University for Science and Technology Gamasa Egypt.
Two new thiadiazole imidazolium salicylidene Schiff bases (TISSBs) were successfully synthesized, and their structures were analyzed comprehensively using spectroscopic techniques. The results of the MTT assay showed that TISSB2 was the safest and most effective anti-breast cancer agent. The anti-angiogenic activity of TISSB2 was evaluated using tests in Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!