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Zinc supplementation improves the outcome of chronic hepatitis C and liver cirrhosis. | LitMetric

AI Article Synopsis

  • A study was conducted on 62 patients with chronic hepatitis C and liver cirrhosis to assess the impact of polaprezinc, which is a zinc supplement, on their long-term health outcomes.
  • Patients receiving polaprezinc showed significantly lower liver enzyme levels (AST and ALT) and less decrease in platelet counts compared to the untreated group.
  • Those who responded positively to the zinc supplementation had a notably lower risk of developing hepatocellular carcinoma (HCC) compared to those who did not respond to the treatment.

Article Abstract

We treated patients with C-viral chronic hepatitis (CH) and liver cirrhosis (LC) with polaprezinc and determined prospectively the effect on long-term outcome. 62 patients were enrolled. Of these, 32 were administered 1.0 g polaprezinc and the remainder were not administered polaprezinc. We measured the serum zinc concentrations using conventional atomic absorption spectrometry and conducted a prospective study to determine the long-term outcome of the polaprezinc therapy. Changes of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in the polaprezinc administration group were significantly lower than those of the untreated group. The decrease in platelet count was clearly less than that of the untreated group. The factors that inhibited increases in serum zinc concentrations following administration of polaprezinc included low serum zinc concentration states. Furthermore, the reductions of AST and ALT levels in the low zinc group were significantly greater than those of the high zinc group. When the patients who were administered polaprezinc were divided into two groups whose zinc concentrations increased (zinc responders) or remained stable or decreased (zinc non-responders), the zinc responders had a clearly lower cumulative incidence of HCC than the zinc non-responders. We conclude zinc supplementation improved the long-term outcome in C-viral CH and LC patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771250PMC
http://dx.doi.org/10.3164/jcbn.08-246DOI Listing

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