Growth hormone receptor gene-disrupted (GHR-/-) mice exhibit increased life span and adipose tissue mass. Although this obese phenotype has been reported extensively for young adult male GHR-/- mice, data for females and for other ages in either gender are lacking. Thus, the purpose of this study was to evaluate body composition longitudinally in both male and female GHR-/- mice. Results show that GHR-/- mice have a greater percent fat mass with no significant difference in absolute fat mass throughout life. Lean mass shows an opposite trend with percent lean mass not significantly different between genotypes but absolute mass reduced in GHR-/- mice. Differences in body composition are more pronounced in male than in female mice, and both genders of GHR-/- mice show specific enlargement of the subcutaneous adipose depot. Along with previously published data, these results suggest a consistent and intriguing protective effect of excess fat mass in the subcutaneous region.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796884 | PMC |
| http://dx.doi.org/10.1093/gerona/glp175 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Diastolic Dysfunction with Normal Ejection Fraction and Reduced Heart Rate in Mice Expressing Human Growth Hormone and Displaying Signs of Growth Hormone Insufficiency.
Int J Mol Sci
December 2024
Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Growth hormone (GH) signaling is essential for heart development. Both GH deficiency and excess raise cardiovascular risk. Human (h) and mouse (m) GH differ structurally and functionally: hGH binds both the GH receptor (GHR) and prolactin receptor (PRLR), whereas mGH binds only GHR; thus, there is the potential for differential effects.
View Article and Find Full Text PDFGrowth hormone receptor in VGLUT2 or Sim1 cells regulates glycemia and insulin sensitivity.
Proc Natl Acad Sci U S A
December 2024
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil.
Growth hormone (GH) has several metabolic effects, including a profound impact on glucose homeostasis. For example, GH oversecretion induces insulin resistance and increases the risk of developing diabetes mellitus. Here, we show that GH receptor (GHR) ablation in vesicular glutamate transporter 2 (VGLUT2)-expressing cells, which comprise a subgroup of glutamatergic neurons, led to a slight decrease in lean body mass without inducing changes in body adiposity.
View Article and Find Full Text PDFRepurposing an epithelial sodium channel inhibitor as a therapy for murine and human skin inflammation.
Sci Transl Med
December 2024
Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Inflammatory skin disease is characterized by a pathologic interplay between skin cells and immunocytes and can result in disfiguring cutaneous lesions and systemic inflammation. Immunosuppression is commonly used to target the inflammatory component; however, these drugs are often expensive and associated with side effects. To identify previously unidentified targets, we carried out a nonbiased informatics screen to identify drug compounds with an inverse transcriptional signature to keratinocyte inflammatory signals.
View Article and Find Full Text PDFSexual dimorphism in the effects of maternal adipose tissue growth hormone receptor deficiency on offspring metabolic health.
Biol Sex Differ
December 2024
Shandong Provincial Hospital, School of Laboratory Animal & Shandong Laboratory Animal Center, Central Hospital Affiliated to Shandong First Medical University, Shandong First Medical University, Jinan, Shandong, 250021, China.
Background: The global incidence of obesity continues to rise, which increases the prevalence of metabolic diseases. We previously demonstrated the beneficial effect of adipose-specific growth hormone receptor (Ghr) knockout (KO) on metabolic parameters in male mice exposed to high fat diet. Although the effect of the growth hormone (GH) axis on lipid metabolism has been well studied, sexual dimorphism has not been considered.
View Article and Find Full Text PDFPromiscuous Janus kinase binding to cytokine receptors modulates signaling efficiencies and contributes to cytokine pleiotropy.
Sci Signal
November 2024
Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Article Synopsis
- Janus kinases (JAKs) play a crucial role in regulating signaling and gene transcription by binding to class I and II cytokine receptors, particularly in the context of type I interferons (IFNs).
- Research showed that modified IFNARs maintain similar IFN signaling levels, while specific versions of IFNAR2 perform poorly despite having necessary docking sites for JAKs and STATs.
- JAKs exhibit promiscuous binding to various cytokine receptors, influencing cross-phosphorylation and signaling efficiency, which contributes to the different signaling outcomes observed in different cell types.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!