Objective: To gain insight into the outcomes of postoperative pain treatment using patient-controlled intravenous analgesia (PCIA) with morphine and oral analgesics after total hip or knee arthroplasty (THA or TKA).
Design: Prospective observational study.
Method: In 2006-2007, 154 THA and 110 TKA patients who underwent arthroplasty at the Medical Centre Alkmaar were included in this study. Postoperative pain treatment consisted of a PCIA pump with morphine and oral analgesics. Primary endpoints were effectiveness of pain treatment and the incidence of side effects.
Results: After THA, 65% of the patients had an acceptable pain score at rest on the day of surgery (day 0), increasing to >95% from 2 days after the operation onwards. On day 1, 43% had an acceptable pain score during movement, increasing to >90% from day 2 onwards. On day 0, nausea occurred in 24% and vomiting in 25% of patients; on day 1, these figures were 21% and 29% respectively. After TKA, 45% of the patients had acceptable pain at rest on day 0, increasing to >or=95% from day 3 onwards. On day 1, pain during movement was acceptable in 24% of the patients, increasing to 80% on day 4. On day 0 following TKA nausea occurred in 37% and vomiting in 39% of patients; on day 1, these figures were 26% and 23%, respectively.
Conclusion: In view of the somewhat disappointing effectiveness and the side effects of a PCIA pump with morphine and oral analgesics, adjustments in the treatment of pain following THA and TKA are required. The greatest improvement can be realised on the day of surgery and the first postoperative day.
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Evolution
January 2025
Department of Ecology, Environment and Plant Sciences, Stockholm University, Stockholm, Sweden.
Accumulating evidence is suggesting more frequent tropical-to-temperate transitions than previously thought. This raises the possibility that biome transitions could be facilitated by precursor traits. A wealth of ecological, genetic and physiological evidence suggests overlap between drought and frost stress responses, but the origin of this overlap, i.
View Article and Find Full Text PDFNicotine Tob Res
January 2025
University of Chicago, Department of Psychiatry and Behavioral Neuroscience, Chicago, IL.
Introduction: Prior research shows that in-person exposure to electronic nicotine delivery systems (ENDS) use increases desire for cigarettes and ENDS. However, less is known about the impact of cues delivered during remote interactions. This study extends previous in-person cue work by leveraging a remote confederate-delivered cue-delivery paradigm to evaluate the impact of dual nicotine vaping (vs.
View Article and Find Full Text PDFCurr Hypertens Rep
January 2025
Department of Internal Medicine, Aristotle University, Hypertension, Hypertension-24h ambulatory blood pressure monitoring center, Papageorgiou Hospital, Thessaloniki, Greece.
Purpose Of The Review: Τhe association between nocturnal blood pressure (BP) and alterations in the retinal microvasculature remains understudied, with few available studies to provide conflicting results. Therefore, we conducted a systematic review and meta-analysis to determine whether an association exists between retinal microvascular alterations and nocturnal BP patterns, determined by 24h ambulatory BP measurement.
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J Mol Histol
January 2025
Department of Histology and Embryology, Faculty of Medicine, Trakya University, Edirne, 22030, Turkey.
Genital tract infections are common causes of male infertility, and most of diagnosed men are asymptomatic. This study examined the effect of gallic acid (GA) against lipopolysaccharide (LPS)-induced testicular inflammation. Thirty-two Spraque Dawley, 2.
View Article and Find Full Text PDFPsychol Res
January 2025
Department of Psychology, Izmir University of Economics, Izmir, Turkey.
The Spatial-Numerical Association of Response Codes (SNARC) effect refers to the phenomenon of faster left-hand responses to smaller numbers and faster right-hand responses to larger ones. The current study examined the possible long-lasting effects of magnitude-relevant stimulus-response compatibility (SRC) practices on the SNARC effect in a transfer paradigm. Participants performed a magnitude classification task including either SNARC-compatible or SNARC-incompatible trials as practice.
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