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Organ Failure and Prediction of Severity in Acute Pancreatitis.
Gastroenterol Clin North Am
March 2025
Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address:
Organ failure (OF) is a sinister development in the clinical course of acute pancreatitis, and its prediction is crucial for triaging the patient. Persistent systemic inflammatory response syndrome and raised interleukin-6 levels have a good predictive accuracy. Pathophysiology involves the release of damage-associated molecular patterns as a consequence of pancreatic injury, recruitment of inflammatory cells, and the release of proinflammatory cytokines and chemokines causing cytokine storm.
View Article and Find Full Text PDFUtility of Thrombopoietin Receptor Agonists (TPO-RAs) for Prolonged Thrombocytopenia After CAR-T Cell Therapy.
Transplant Cell Ther
January 2025
The University of Chicago Medical Center, Chicago IL.
Background: Chimeric Antigen Receptor T-cell (CAR-T) therapy has revolutionized the treatment landscape for various hematological malignancies. However, it is associated with a range of hematologic complications, including severe and often prolonged thrombocytopenia. Currently, there are no known effective preventative or management measures against CAR-T-induced thrombocytopenia.
View Article and Find Full Text PDFSafety and Efficacy of Fingolimod and Ocrelizumab in Pediatric Patients With Multiple Sclerosis.
Pediatr Neurol
January 2025
Division of Pediatric Neurology, Department of Neurology, University of Virginia, Charlottesville, Virginia. Electronic address:
Background: Fingolimod and ocrelizumab are approved treatments for adults with multiple sclerosis (MS); however, only fingolimod is approved by the Food and Drug Administration for the treatment of pediatric MS. Currently, there are limited data for the safety and efficacy of ocrelizumab use in children.
Methods: This retrospective cohort study included patients with relapsing-remitting MS who started either ocrelizumab or fingolimod before age 18 years.
Antimicrobial Susceptibility of Clinical Isolates of Stenotrophomonas maltophilia Isolates from Europe, Asia, and Latin America (2018-2023).
Int J Infect Dis
January 2025
Element Iowa City (JMI Laboratories), North Liberty, IA, USA.
Background: The occurrence of Stenotrophomonas maltophilia infections, especially pneumonia, has increased consistently in the last years. We evaluated the antimicrobial susceptibility of a large collection of S. maltophilia collected in Europe, Asia, and Latin America.
View Article and Find Full Text PDFAssessment of a New CT Detector and Filtration Technology: Part 2-Image Quality in Phantoms, Cadavers, and Patients.
J Comput Assist Tomogr
January 2025
Department of Radiology, College of Medicine, University of Florida, Gainesville, FL.
Purpose: The purpose of this work was to evaluate the image quality of a commercial CT scanner equipped with a novel detector and filtration technology called PureVision Optics (PVO).
Methods: CT number, noise, contrast-to-noise ratio (CNR), modulation transfer function (MTF), and noise power spectrum (NPS) were assessed using the ACR CT Accreditation phantom scanned with various acquisitions at 80 kV, 100 kV, 120 kV, and 135 kV, each with multiple CTDIvol values of 20 mGy, 40 mGy, and 65 mGy. Artifacts were evaluated in an anthropomorphic head phantom, a cadaver head, and in patient studies.
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