[The hypothalamic-pituitary-adrenal axis, and reproductive system activity changing of female rats with prenatal stress during aging].

The effect of female rat daily 1-hour immobilization in the period from the 15th to the 18th gestation days on the sex steroid secretion subject to estrous cycle, hypothalamic-pituitary-adrenal axis (HPA) activity and its sensitivity to regulatory signals based on the mechanism of negative feedback in ternale offspring during different ontogenesis stages, was studied. It has been shown that prenatal stress causes significant reproductive system activity disturbances, leading to a significant decrease in the HPA sensitivity to feedback signal in aging female rats. The obtained data indicate a modifying influence of mothers' stress on changing of female rat reproductive functions during aging together with influence on significant decrease in efficiency of HPAs' feedback path.