[Expression of splice-variants of the insulin-like growth factor I and the condition of the cell-myosatellite pool in the rat m. soleus under conditions of gravitation relief and passive stretching].

We suggested that satellite proliferation with subsequent incorporation of their nuclei in the fibres was essential for enhancement of the protein synthesis in the rat relieved m. soleus. In passive stretch of the muscle, the number of labelled cells exceeded 2.5-fold their number in hung out animals and 1.7-fold in the control animals. The expression level of the insulin-like growth factor I (IF-1) was determined in the m. soleus after hanging out with stretching, and no changes were revealed as compared with hanging out without stretching in the control group. We believe that the muscle IF-1 and satellite cell incorporation are not essential for preventing atrophy of relieved soleus muscle in stretching.