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Improved phosphorus MRSI acquisition through compressed sensing acceleration combined with low-rank reconstruction.
MAGMA
December 2024
Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Objectives: Phosphorus-31 magnetic resonance spectroscopic imaging (P-MRSI) is a non-invasive tool for assessing cellular high-energy metabolism in-vivo. However, its acquisition suffers from a low sensitivity, which necessitates large voxel sizes or multiple averages to achieve an acceptable signal-to-noise ratio (SNR), resulting in long scan times.
Materials And Methods: To overcome these limitations, we propose an acquisition and reconstruction scheme for FID-MRSI sequences.
QSAR-guided strategy for accurate annotation of FAHFA regioisomers.
Talanta
December 2024
Department of Chemistry, Wuhan University, Wuhan, 430072, China; School of Bioengineering and Health, Wuhan Textile University, Wuhan, 430200, China; Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, 430071, China. Electronic address:
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) represent a novel class of bioactive lipids with significant physiological roles. However, their identification, particularly of low-abundance FAHFA regioisomers, remains challenging due to their high structural similarity, low natural abundance, and the limited availability of reliable FAHFA standards. In this study, we present a QSAR-based FAHFA annotation strategy that integrates a QSAR model with an ester bond position (EP) rule to determine the EPs of FAHFA regioisomers.
View Article and Find Full Text PDFInhibition of the mitochondrial permeability transition pore as a promising target for protecting auditory function in cisplatin-induced hearing loss.
Biomed Pharmacother
December 2024
Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea; School of Life Sciences, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Republic of Korea. Electronic address:
mPTP is a multi-protein complex that opens in mitochondria during cell death. Cisplatin-induced hearing loss is also known to be caused by mPTP opening. Thus, our study evaluated the protective effect of a novel mPTP inhibitor named DBP-iPT against cisplatin-induced hearing loss.
View Article and Find Full Text PDFA new strategy for enhancing S-Adenosyl-L-Methionine (SAMe) oral bioavailability: Preparation of SAMe loaded inulin nanoparticles for colon targeting with in vivo validation.
Int J Biol Macromol
December 2024
Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Ankara, Turkey. Electronic address:
S-Adenosylmethionine (SAMe) is a crucial endogenous molecule in vital biochemical processes such as DNA, RNA, and protein methylation. It has been found beneficial in the treatment of liver disease, osteoarthritis, and particularly depression. However, SAMe's therapeutic potential is limited by low bioavailability due to poor permeability and extensive liver metabolism.
View Article and Find Full Text PDFData science shows that entropy correlates with accelerated zeolite crystallization in Monte Carlo simulations.
J Chem Phys
December 2024
Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA.
We have performed a data science study of Monte Carlo (MC) simulation trajectories to understand factors that can accelerate the formation of zeolite nanoporous crystals, a process that can take days or even weeks. In previous work, MC simulations predicted and experiments confirmed that using a secondary organic structure-directing agent (OSDA) accelerates the crystallization of all-silica LTA zeolite, with experiments finding a three-fold speedup [Bores et al., Phys.
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