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Studies on curative efficacy of monoterpene eugenol on anti- leukemic drug arsenic trioxide induced cardiotoxicity.
Biomed Pharmacother
July 2017
Physiology Research Laboratory, School of Biosciences, Mahatma Gandhi University, Kerala 686 560, India. Electronic address:
Background: Arsenic trioxide (AsO) is emerging as a frontline agent for the treatment of acute promyelocytic leukemia (APL) but the therapeutic application is limited by its toxicity. QT prolongation, torsades de pointes and sudden cardiac death have been implicated in the AsO therapy. So eugenol is a monoterpene compound is well known for its antioxidant properties and protective effect on the cardiovascular system.
View Article and Find Full Text PDFMechanisms of arsenic-induced prolongation of cardiac repolarization.
Mol Pharmacol
July 2004
Rammelkamp Center, MetroHealth Medical Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.
Arsenic trioxide (As(2)O(3)) produces dramatic remissions in patients with relapsed or refractory acute promyelocytic leukemia. Its clinical use is burdened by QT prolongation, torsade de pointes, and sudden cardiac death. In the present study, we analyzed the molecular mechanisms leading to As(2)O(3)-induced abnormalities of cardiac electrophysiology.
View Article and Find Full Text PDFTorsades de pointes in 3 patients with leukemia treated with arsenic trioxide.
Blood
March 2001
Our Lady of Mercy Cancer Center and Division of Cardiology, Our Lady of Mercy Medical Center, Bronx, NY 10466, USA.
Arsenic trioxide is used in clinical trials in the treatment of relapsed and resistant cases of acute promyelocytic leukemia. Adverse effects from arsenic in these studies have been multisystemic. Arsenic is known to cause corrected QT-interval prolongation and T-wave changes, but the potential for serious ventricular arrhythmias is less well understood.
View Article and Find Full Text PDFArsenic-induced torsade de pointes.
Crit Care Med
February 1991
Department of Medicine, University of Illinois, Chicago 60612.
Torsade de pointes and T-U wave alternans associated with arsenic poisoning.
Pacing Clin Electrophysiol
February 1990
Department of Medicine, University of Alabama, Birmingham 35294.
Arsenic intoxication is a common form of heavy metal poisoning. Although arsenic-induced circulatory collapse, seizures, and syncope are well known, the potential for serious ventricular arrhythmias is less well recognized. Reported in this study are two cases of arsenic poisoning causing torsade de pointes.
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