A series of tetrahydroquinoline-derived inhibitors of the CRTH2 receptor was discovered by a high throughput screen. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent and orally bioavailable CRTH2 antagonists.
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| http://dx.doi.org/10.1016/j.bmcl.2009.10.094 | DOI Listing |
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