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http://dx.doi.org/10.1016/j.advenzreg.2009.10.011 | DOI Listing |
Res Sq
October 2024
Department of Biology, Volen National Center for Complex Systems, Brandeis University, Waltham, MA 02454-9110, USA.
Neuronal dense core vesicles (DCVs) store and release a diverse array of neuromodulators, trophic factors and bioamines. The analysis of single DCVs has largely been possible only using electron microscopy, which makes understanding cargo segregation and DCV heterogeneity difficult. To address these limitations, we developed genetically-encoded markers for DCVs that can be used in combination with standard immunohistochemistry and expansion microscopy, to enable single-vesicle resolution with confocal microscopy.
View Article and Find Full Text PDFAm J Surg Pathol
January 2025
Department of Pathology, The Medical College of Wisconsin, Milwaukee, WI.
A distinctive form of lung adenocarcinoma that closely mimics large-cell neuroendocrine carcinoma is described. The tumors arose in 6 women and 6 men aged 46-86 years (mean=58.4).
View Article and Find Full Text PDFbioRxiv
October 2024
Department of Biology, Volen National Center for Complex Systems, Brandeis University, Waltham, MA 02454-9110, USA.
Neuronal dense core vesicles (DCVs) store and release a diverse array of neuromodulators, trophic factors and bioamines. The analysis of single DCVs has largely been possible only using electron microscopy, which makes understanding cargo segregation and DCV heterogeneity difficult. To address these limitations, we developed genetically-encoded markers for DCVs that can be used in combination with standard immunohistochemistry and expansion microscopy, to enable single-vesicle resolution with confocal microscopy.
View Article and Find Full Text PDFACS Omega
October 2024
State Key Laboratory of Oil & Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu, Sichuan 610500, China.
J Mech Behav Biomed Mater
August 2024
Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran. Electronic address:
The aim of this study is to compare the stress distribution in porous scaffolds with different structures with similar geometric parameters to study a new approach in dental implantation. Three-dimensional finite element models of the fully porous and dense-core porous scaffolds with defined porosity parameters including space diameter and thickness with two porosity patterns were embedded in the jaw bone model with cortical and cancellous bone. The cylindrical shape was considered as the main shape of the scaffolds.
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