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USP44 regulates HEXIM1 stability to inhibit tumorigenesis and metastasis of oral squamous cell carcinoma.
Biol Direct
December 2024
Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, 1 Longhu Zhonghuan Road, Jinshui District, Zhengzhou, Henan, 450001, China.
Oral squamous cell carcinoma (OSCC) is the most frequent type of oral malignancy with high metastasis and poor prognosis. The deubiquitinating enzyme Ubiquitin Specific Peptidase 44 (USP44) regulates the mitotic checkpoint, and its deficiency leads to aneuploidy and increases tumor incidence. However, the role of USP44 in OSCC is not well understood.
View Article and Find Full Text PDFGenetic diversity and population structure of Alternaria alternata: An endophytic fungus isolated from various hosts.
Fungal Biol
December 2024
Nuclear Agriculture Research School, Nuclear Science and Technology Research Institute (NSTRI), Karaj, Iran.
Article Synopsis
- - Alternaria alternata is a fungal species that can act as both a plant pathogen and an endophyte, enhancing plant growth while studying its genetic diversity sheds light on its evolution with host plants.
- - Research involved examining genetic variation in A. alternata from different plant hosts using ten ISSR primers, yielding 65 polymorphic bands and revealing higher genetic diversity in isolates from Gundelia tournefortii compared to Tamarix ramosissima.
- - Results indicated significant genetic differentiation among A. alternata populations (72% within populations), suggesting strong genetic structure and potential factors like sexual reproduction or mitotic recombination influencing this diversity.
Luciferase-Based Reporter Assay for the Assessment of Aurora A-Kinase Activity in Mitotic Cycle.
Methods Mol Biol
November 2024
Molecular Cancer Genetics & Translational Research Lab, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh, UP, India.
Luciferase-based reporter assay is an important tool that employs bioluminescence to quickly and precisely investigate the gene of interest's promoter activity by reporter gene expression at the transcriptional level. The promoter of the gene of interest is fused with the reporter gene (a gene that produces luciferase enzymes) and then transfected into the cells. Luciferase is an enzyme that catalyzes a chemical reaction to produce light.
View Article and Find Full Text PDFRAD52 and ERCC6L/PICH have a compensatory relationship for genome stability in mitosis.
PLoS Genet
November 2024
Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, California, United States of America.
Mammalian RAD52 is a DNA repair factor with strand annealing and recombination mediator activities that appear important in both interphase and mitotic cells. Nonetheless, RAD52 is dispensable for cell viability. To query RAD52 synthetic lethal relationships, we performed genome-wide CRISPR knock-out screens and identified hundreds of candidate synthetic lethal interactions.
View Article and Find Full Text PDFNuclear pore complexes undergo Nup221 exchange during blood-stage asexual replication of parasites.
mSphere
December 2024
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Unlabelled: parasites, the causative agents of malaria, undergo closed mitosis without breakdown of the nuclear envelope. Unlike closed mitosis in yeast, parasites undergo multiple rounds of asynchronous nuclear divisions in a shared cytoplasm. This results in a multinucleated organism prior to the formation of daughter cells within an infected red blood cell.
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