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Clinical outcomes and biomechanics in bicruciate-retaining total knee arthroplasty.
J Exp Orthop
January 2025
Department of Orthopaedic Surgery, Faculty of Medicine The University of Tokyo Tokyo Japan.
Purpose: To clarify the influence of biomechanics on post-operative clinical outcomes in bicruciate-retaining total knee arthroplasty (BCR-TKA).
Methods: Severe medial osteoarthritis who underwent BCR-TKA were examined. Each patient was asked to perform a squat (weight-bearing [WB]) and active assisted knee flexion (non-WB [NWB]) under single fluoroscopy surveillance.
Environmental shocks and migration among a climate-vulnerable population in Bangladesh.
Popul Environ
January 2025
Center for Comparative and International Studies (CIS), ETH Zurich, 8092 Zurich, Switzerland.
Unlabelled: Various studies predict large migration flows due to climatic and other environmental changes, yet the ex post empirical evidence for such migration is inconclusive. To examine the causal link between environmental changes and migration for a population residing along the Jamuna River in Bangladesh, an area heavily affected by floods and riverbank erosion, I relate the respondents' self-reported affectedness by environmental changes, their migration aspirations, and their capability to move to their migration likelihood. The analysis relies on a unique quasi-experimental research design based on original survey panel data of 1604 household heads.
View Article and Find Full Text PDFImproving clinical care of patients in Nipah outbreaks: moving beyond 'compassionate use'.
Lancet Reg Health Southeast Asia
February 2025
Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
The 2024 Nipah outbreak in Kerala, India-its fifth in six years-and the recurring annual outbreaks in Bangladesh underscore the persistent threat posed by the Nipah virus (NiV) in the region. With a high mortality rate, human-to-human transmission potential, and the widespread presence of bats, the natural reservoir, NiV remains a significant epidemic threat. Despite being a WHO priority pathogen, there has been no systematic effort to improve patient care for NiVD, leading to consistently poor outcomes.
View Article and Find Full Text PDFLocation and Movement of the Oxytocin Receptor Differ Between the Normal and Diseased Prostate.
Cancers (Basel)
January 2025
Department of Anatomy, University of Otago, P.O. Box 913, Dunedin 9054, New Zealand.
Background: In normal prostate cells, receptors for oxytocin (OT), a peptide involved in regulating prostate growth are sequestered within membrane microdomains called caveolae. During cancer progression, polymerase-transcript-release factor (PTRF) is downregulated, caveolae structures are lost and receptors move onto the cell membrane. This study investigated whether proteins responsible for caveolae formation were affected by the OT peptide, also, how OT treatment affected oxytocin receptor (OTR) movement within living cells.
View Article and Find Full Text PDFIntegrated Management of Cardiovascular-Renal-Hepatic-Metabolic Syndrome: Expanding Roles of SGLT2is, GLP-1RAs, and GIP/GLP-1RAs.
Biomedicines
January 2025
Department of Cardiology & Preventive Cardiology Outpatient Clinic, Amalia Fleming General Hospital, 14, 25th Martiou Str., 15127 Melissia, Greece.
Cardiovascular-Kidney-Metabolic syndrome, introduced by the American Heart Association in 2023, represents a complex and interconnected spectrum of diseases driven by shared pathophysiological mechanisms. However, this framework notably excludes the liver-an organ fundamental to metabolic regulation. Building on this concept, Cardiovascular-Renal-Hepatic-Metabolic (CRHM) syndrome incorporates the liver's pivotal role in this interconnected disease spectrum, particularly through its involvement via metabolic dysfunction-associated steatotic liver disease (MASLD).
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