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Development of Behçet's disease on maintenance therapy for autoimmune hepatitis.
BMJ Case Rep
December 2024
Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
Behçet's disease is a clinical diagnosis with variable presentations. Liver involvement is rare in the absence of vascular complications. We describe a patient diagnosed with Hashimoto's thyroiditis and autoimmune hepatitis on azathioprine who developed extensive aphthous ulcers approximately 10 years later.
View Article and Find Full Text PDFExploring cardiovascular implications in systemic lupus erythematosus: A holistic analysis of complications, diagnostic criteria, and therapeutic modalities, encompassing pharmacological and adjuvant approaches.
Biomol Concepts
January 2024
College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, 91766, United States of America.
Systemic lupus erythematosus (SLE) poses a diagnostic challenge due to its heterogeneity. This study examines the cardiac complications of SLE comprehensively, covering pericarditis, myocarditis, pleural effusion, valvular disease, atherosclerosis, and cardiac arrhythmias. Nearly one-third of SLE-related deaths are attributed to cardiovascular diseases, necessitating a deeper understanding of cardiac pathophysiology.
View Article and Find Full Text PDFNovel Treatments in Refractory Recurrent Pericarditis.
Pharmaceuticals (Basel)
August 2024
First Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Vas. Sofias 114, 11527 Athens, Greece.
Refractory recurrent pericarditis is a troublesome condition that severely impairs the quality of life of affected patients and significantly increases healthcare spending. Until recently, therapeutic options included only a few medications and most of the patients resorted to chronic glucocorticoid treatment with steroid dependence. In the most recent decade, the introduction of interleukin-1 blockers in clinical practice has revolutionized the treatment of glucocorticoid-dependent and colchicine-resistant recurrent pericarditis due to their excellent efficacy and good safety profile.
View Article and Find Full Text PDFCalcium pyrophosphate deposition disease.
Lancet Rheumatol
November 2024
Academic Rheumatology, University of Nottingham, Nottingham, UK; NIHR Nottingham Biomedical Research Centre, Nottingham, UK.
Article Synopsis
- - Calcium pyrophosphate deposition disease (CPPD) occurs when CPP crystals build up in joints, triggering inflammation and arthritis, particularly in older individuals over 60, and is linked to cartilage deterioration and osteoarthritis.
- - Common risk factors for CPPD include aging, past joint injuries, and certain metabolic conditions or genetic factors. Diagnosis relies on detecting CPP crystals in joint fluid and imaging techniques like X-rays and ultrasound.
- - Current treatment focuses on managing inflammation since there’s no cure for dissolving CPP crystals; options include prednisone for acute arthritis, low-dose colchicine, and potential use of biologics for stubborn cases.
Cardiac Tamponade as The Initial Presentation of Childhood Systemic Lupus Erythematosus: A Case Report.
Niger Med J
April 2024
Department of Paediatrics, University of Uyo Teaching Hospital, Uyo, Nigeria.
Article Synopsis
- - Systemic Lupus Erythematosus (SLE) is an autoimmune disease leading to various organ damage, and in children, it often presents with symptoms like fever, joint pain, and skin rashes, but initial cardiac issues like large pericardial effusions are rare.
- - An 11-year-old girl was admitted with severe respiratory distress, leg swelling, and quick heart rate; imaging revealed a large pericardial effusion, leading to a procedure that drained 650ml of fluid which showed inflamed tissue but no cancerous cells.
- - She was treated with medications including corticosteroids and remains stable, highlighting the need for careful evaluation for autoimmune disorders in children presenting with significant heart-related
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