Introduction: Food-dependent exercise-induced anaphylaxis (FDEIA) is an uncommon and under-recognised syndrome that clinicians may not consider in a patient presenting with anaphylaxis.
Clinical Picture: We describe here 5 patients aged 9 to 20 years old who presented at a local tertiary hospital over a 2-year period from August 2006 to July 2008. All presented with urticaria, 4 were hypotensive, 2 had angioedema and another 2 had dyspnoea. The symptoms occurred between 15 and 150 minutes (mean, 81) after exercising and consuming various food. All had consumed shellfish. All patients were admitted with the diagnosis of anaphylaxis of undefined aetiology. Diagnosis of FDEIA was only reached upon referral to an allergist.
Treatment And Outcome: Patients were treated with standard medicines for anaphylaxis including adrenaline, antihistamines, steroids and fluid flushes. Symptoms resolved in 2 to 3 days with no further episodes. At discharge, patients were prescribed epinephrine auto-injectors and given written anaphylaxis management plans.
Conclusions: More public awareness and strategies to ensure accurate diagnosis and management of this condition are necessary.
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Clin Exp Allergy
December 2024
Department of Dermatology and Allergy Centre, Odense Research Center for Anaphylaxis (ORCA), Odense University Hospital, Odense C, Denmark.
Front Allergy
October 2024
Allergy and Immunology Division, Department of Medicine, Hamad Medical Corporation, Doha, Qatar.
Food-dependent exercise-induced anaphylaxis (FDEIA) is a rare and complex clinical condition in which allergic reactions are triggered by specific foods combined with physical activity, even though the food allergen and exercise are tolerated individually. Wheat is the most common culprit food leading to wheat dependent exercise induced anaphylaxis (WDEIA). Management of FDEIA is challenging due to the unpredictability of attacks and the lack of approved prophylactic medications.
View Article and Find Full Text PDFCurr Allergy Asthma Rep
November 2024
Department of Pediatrics, Division of Pulmonology, Allergy & Immunology, University of Tennessee Health Science Center, LeBonheur Children's Hospital, 51 N. Dunlap Street, Suite 400, Memphis, TN, 38105, USA.
J Allergy Clin Immunol Glob
November 2024
Department of Immunology, Beaumont Hospital, Dublin, Ireland.
Asia Pac Allergy
August 2024
Department of Allergy, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
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