Selecting the most appropriate test species for sediment and water column assays has been a primary goal for ecotoxicologists. Standard test organisms and established test guidelines exist, but the USEPA-recommended species may not be the most sensitive organisms to anthropogenic inputs. This paper describes preliminary results of toxicity tests with the mayfly, Isonychia bicolor (Ephemeroptera). Results suggested that Isonychia were moderately sensitive to NaCl after 96 h with an average LC(50) value of 3.10 g NaCl per liter. This value decreased after 7 days of exposure, resulting in a mean LC(50) value of 1.73 g NaCl per liter. When exposed to a coal-mine-processed effluent, Isonychia generated LC(50) values that ranged from 13% to 39% effluent. I. bicolor were more sensitive to the coal processing effluent than Ceriodaphnia dubia with conductivity lowest observable effects concentration (LOEC) values for mayfly survivorship that ranged from 1,508 to 4,101 microS/cm, while LOEC values for C. dubia reproduction ranged from 2,132 to 4,240 microS/cm.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10661-009-1191-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Gender and sex differences in colorectal cancer screening, diagnosis and treatment.
Clin Transl Oncol
January 2025
Department of Medical Oncology, University Hospital of Navarra, Instituto de Investigación Sanitaria de Navarra, IdISNA, Navarra, Spain.
Males have a higher incidence and mortality rate from colorectal cancer (CRC) compared with females. This review examines the reasons for these differences, including risk factors, screening participation, interpretation of screening tests, presentation and tumour types, pathophysiology (particularly the impact of sex hormones on tumour-related gene expression, microsatellite instability, micro-RNA expression, and the tumour microenvironment), and the efficacy and toxicity of treatment. Sex differences in hormones and body composition are responsible for some of the sexual dimorphism in CRC incidence and outcomes, particularly the pathophysiology, CRC presentation, the pharmacokinetics of cytotoxic therapies, and the impact of treatment on outcomes.
View Article and Find Full Text PDFA phase I study of MLN4924 and belinostat in relapsed/refractory acute myeloid leukemia or myelodysplastic syndrome.
Cancer Chemother Pharmacol
January 2025
Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Purpose: Relapsed and/or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome continue to have a poor prognosis with limited treatment options despite advancements in rational combination and targeted therapies. Belinostat (an HDAC inhibitor) and Pevonedistat (a NEDD8 inhibitor) have each been independently studied in hematologic malignancies and have tolerable safety profiles with limited single-agent activity. Preclinical studies in AML cell lines and primary AML cells show the combination to be highly synergistic, particularly in high-risk phenotypes such as p53 mutant and FLT-3-ITD positive cells.
View Article and Find Full Text PDFA Real-World Disproportionality Analysis of Histamine H2-Receptors Antagonists (Famotidine): A Pharmacovigilance Study Based on Spontaneous Reports in the FDA Adverse Event Reporting System.
Drug Dev Res
February 2025
Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Famotidine is an H2 receptor antagonist and is currently used on a large scale in gastroenterology. However, Famotidine may also cause severe toxicity to organ systems, including the blood system, digestive system, and urinary system. The objective of this study was to scientifically and systematically investigate the adverse events (AEs) of Famotidine in the real world through the FDA Adverse Event Reporting System (FAERS) database.
View Article and Find Full Text PDFVisualization of labeled micro- and nanoplastics in interaction with algae, using super-resolution stimulated emission depletion microscopy and fluorescence lifetime imaging.
Environ Toxicol Chem
January 2025
Blue Growth Research Lab, Ghent University, Ostend Science Park, Ostend, Belgium.
In contrast to microplastics, studying the interactions of nanoplastics (NPs) with primary producers such as marine microalgae remains challenging. This is attributed to the lack of adequate visualization methods that can distinguish NPs from autofluorescent biological material such as marine algae. The aim of this study was to develop a method for labeling and visualizing nonfluorescent micro- and nanoplastics (MNPs) of various polymer types, shapes, and sizes, in interaction with marine primary producers, which are autofluorescent.
View Article and Find Full Text PDFComparing laboratory toxicity of selective intra-arterial radionuclide therapy for primary and metastatic liver tumors: resin versus glass microspheres.
Ann Nucl Med
January 2025
Department of Nuclear Medicine, Hacettepe University Faculty of Medicine, Ankara, Türkiye.
Objective: To compare the acute (within 30 days of treatment) laboratory toxicities of Yttrium-90 (Y-90) resin and glass microspheres.
Methods: Selective intra-arterial radionuclide therapies (SIRTs) with Y-90 resin and glass microspheres were retrospectively reviewed. Liver-hematological data were collected at baseline and at 1 week and 1 month follow-up.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!