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Acute Myeloid Leukemia (AML) With T-Cell Differentiation Arising From Chronic Myelomonocytic Leukemia (CMML).
Case Rep Hematol
December 2024
Department of Pathology and Laboratory Medicine, University of California Irvine (UCI) Medical Center, Orange, USA.
Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm characterized by peripheral blood monocytosis and bone marrow dysplasia. In approximately one-fourth of cases, CMML can demonstrate progression to acute myeloid leukemia (AML), referred to as AML ex CMML. We present a 58-year-old woman with a past medical history of idiopathic thrombocytopenic purpura (ITP) who demonstrated 24% bone marrow blasts on a repeat biopsy obtained two years after being diagnosed with CMML.
View Article and Find Full Text PDFThe spectrum of Ph-negative disease: CNL and CSF3R-related disorders.
Hematology Am Soc Hematol Educ Program
December 2024
Department of Pathology, Massachusetts General Hospital, Boston, MA.
Chronic neutrophilic leukemia (CNL) is a very rare myeloid neoplasm characterized by peripheral blood neutrophilia and a hypercellular marrow with increased granulopoiesis. An activating mutation in CSF3R is present in 80% to 90% of cases. CNL displays some biological overlap in terms of clinical presentation and behavior, as well as genetic profile, with several other myeloid neoplasms, particularly myelodysplastic/myeloproliferative neoplasms (MDS/MPN) and other MPN.
View Article and Find Full Text PDFFLAER Revealed Normally Expected Non-PNH FLAER-Dim Immature Myeloid Cells (CD117+/CD34-) In Bone Marrow Aspirates and Could Be Utilized as a Marker of Hierarchical Hematopoiesis.
Int J Lab Hematol
October 2024
Department of Immunology, General Hospital of Athens "G. Gennimatas", Athens, Greece.
Article Synopsis
- FLAER (Fluorescently labeled aerolysin) is used to identify PNH clones in blood samples, but there's limited information on its expression in normal bone marrow cells.
- This study analyzed 54 bone marrow samples from various conditions, including PNH and different types of leukemia, to understand FLAER expression in both normal and diseased hematopoiesis.
- Results showed that while FLAER intensity was generally intermediate in stem cells, a specific FLAER-negative subgroup was found in PNH patients, indicating varying expression levels in myeloid precursors across different conditions.
Can molecular patterns help to classify overlapping entities in myeloid neoplasms?
Histopathology
January 2025
Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, USA.
Myeloid neoplasms include myeloproliferative and myelodysplastic neoplasms and acute myeloid leukaemia. Historically, these diseases have been diagnosed based on clinicopathological features with sometimes arbitrary thresholds that have persisted even as molecular features were gradually incorporated into their classification. As such, although current diagnostic approaches can classify the majority of myeloid neoplasms accurately using a combination of molecular and clinicopathological features, some areas of overlap persist and occasionally pose diagnostic challenges.
View Article and Find Full Text PDFGastric Bleeding in Stem Cell Transplantation: A Focus on Gastric Vascular Ectasia Under Post-Transplant Cyclophosphamide, Sirolimus, and Mycophenolate Mofetil Prophylaxis.
Transplant Cell Ther
October 2024
Hospital Universitari i Politècnic La Fe, Valencia, Spain; Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain; Departamento de Medicina, Universidad de Valencia, Valencia, Spain; CIBERONC, Instituto Carlos III, Madrid, Spain.
Gastrointestinal bleeding (GIB) is a serious complication following allogeneic hematopoietic stem cell transplantation (HSCT), with limited data on its incidence and characteristics, particularly for upper gastrointestinal bleeding (UGIB) of gastric origin. We aimed to evaluate the incidence, clinical, endoscopic, and histopathologic features, and outcomes of UGIB, with a focus on gastric vascular ectasias (GVEs) in patients undergoing HSCT with graft-versus-host disease (GVHD) prophylaxis using post-transplant cyclophosphamide (PTCY), sirolimus or calcineurin inhibitors, and mycophenolate mofetil. This retrospective, single-center study included all adult patients who underwent allogeneic HSCT at a single institution between January 2017 and December 2023.
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