Accident reconstructionists are often faced with damage patterns and locations on vehicles that are not well defined by available barrier impact data. One such example is a frontal underride collision. Underride impacts occur when there is a height mismatch between the primary structural components of the impacting vehicles, and the vehicle with the lower height is forced beneath the structure of the other vehicle. The lack of structural engagement typically allows for significantly different damage patterns due to the inherently lower stiffness of the underriding vehicle's contacting surfaces coupled with complex interactions between varying surfaces. In this study, a series of two-vehicle impact tests between a small pickup (bullet vehicle) and a large dump truck (target vehicle) were performed and studied. These tests involved a severe underride configuration in which the dump truck bed's vertical alignment was above the base of the windshield of the pickup. Coupled with these impacting surfaces was a single vertical support, a remnant of a commonly referred to ICC (Interstate Commerce Commission) bumper, which caused a narrow object-type impact, but did not extend down to the pickup's bumper. Multiple prior authors' analytical and empirical relationships to predict impact speed based on crush damage were evaluated using the results of these tests as well as other published underride tests. No single model was sufficient at predicting the mixed mode of impact present in these impact scenarios. However, a system of equations was developed to predict the impact parameters utilizing a combination of previously reported methods and a new empirical relationship presented in this study. This new method shows high correlation and supports the authors' hypothesis that separate crush models can be applied to multiple discrete areas of a vehicle and then combined to form a more complete predictive systematic model.
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http://dx.doi.org/10.1016/j.aap.2009.07.015 | DOI Listing |
Acupunct Med
January 2025
Combination of Acupuncture and Medicine Innovation Research Center, Shaanxi University of Chinese Medicine, Xianyang, China.
Objective: Cognitive impairment (CI) is highly prevalent in subarachnoid hemorrhage (SAH) patients. The phosphatidylinositol 3-kinase (PI3K)/AKT pathway plays a critical role in neuronal survival in a variety of central nervous system injuries. This study aimed to determine whether electroacupuncture (EA) at and LI20 ameliorates SAH-CI in a rat model and to examine whether it modulates the PI3K/AKT pathway by administering a PI3K inhibitor (LY294002) versus dimethyl sulfoxide (DMSO) vehicle.
View Article and Find Full Text PDFAlzheimers Dement (Amst)
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BMJ Oncol
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Department of Medicine, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.
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BMC Plant Biol
January 2025
Institute of Biology, Fundamental and Applied Research in Chemical Ecology, University of Neuchâtel, Neuchâtel, Switzerland.
Background: Upland cotton (Gossypium hirsutum) plants constitutively store volatile terpenes in their leaves, which are steadily emitted at low levels. Herbivory leads to a greater release of these stored volatiles. Additionally, damaged plants increase the accumulation of volatile terpenes in their leaves and begin to synthesize and emit other terpenes and additional compounds.
View Article and Find Full Text PDFThorax
January 2025
Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge, UK.
Acute respiratory distress syndrome (ARDS) is present in >10% of all people admitted to critical care and is associated with severe morbidity and mortality. Despite more than half a century since its first description, no efficacious pharmacological therapies have been developed, and little progress has been made in improving clinical outcomes. Neutrophils are the principal drivers of ARDS, with their priming and subsequent aberrant downstream functions, including interleukin (IL) 1β and IL-18 secretion, central to the disease pathogenesis.
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