Compliance to standardized highway design criteria is considered essential to ensure roadway safety. However, for a variety of reasons, situations arise where exceptions to standard-design criteria are requested and accepted after review. This research explores the impact that such design exceptions have on the frequency and severity of highway accidents in Indiana. Data on accidents at carefully selected roadway sites with and without design exceptions are used to estimate appropriate statistical models of the frequency and severity of accidents at these sites using recent statistical advances with mixing distributions. The results of the modeling process show that presence of approved design exceptions has not had a statistically significant effect on the average frequency or severity of accidents - suggesting that current procedures for granting design exceptions have been sufficiently rigorous to avoid adverse safety impacts. However, the findings do suggest that the process that determines the frequency of accidents does vary between roadway sites with design exceptions and those without.
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http://dx.doi.org/10.1016/j.aap.2009.07.013 | DOI Listing |
Environ Sci Pollut Res Int
December 2024
Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, 163 Horria Ave. El-Shatby, P.O. Box 832, Alexandria, Egypt.
Phenol is a highly concerning pollutant in petrochemical industrial wastewater. It is extremely poisonous, carcinogenic, and persistent, therefore, it bioaccumulates in the food chain reaching humans, where it causes acute irritation to the skin, eyes, and respiratory tract, as well as chronic effects on the liver, kidneys, and nervous system. It spills or leaks easily into surface water or groundwater sources, leading to the creation of other harmful substituted compounds.
View Article and Find Full Text PDFRadiother Oncol
December 2024
Department of Digital Medicine, School of Biomedical Engineering and Medical Imaging, Army Medical University, Chongqing 400038, China. Electronic address:
Background And Purpose: Accurate segmentation of the clinical target volume (CTV) is essential to deliver an effective radiation dose to tumor tissues in cervical cancer radiotherapy. Also, although automated CTV segmentation can reduce oncologists' workload, challenges persist due to the microscopic spread of tumor cells undetectable in CT imaging, low-intensity contrast between organs, and inter-observer variability. This study aims to develop and validate a multi-task feature fusion network (MTF-Net) that uses distance-based information to enhance CTV segmentation accuracy.
View Article and Find Full Text PDFEur J Obstet Gynecol Reprod Biol
December 2024
Department of Gynaecological Oncology, West Kent Cancer Centre, Maidstone and Tunbridge Wells NHS Trust, Hermitage Lane, Maidstone, Kent ME16 9QQ, United Kingdom.
Objective: During the treatment of ovarian cancer, the risk of venous thromboembolism (VTE) post operatively is well established, however, patients may be at even greater risk during neoadjuvant chemotherapy (NACT). This study aimed to determine the incidence and timing of VTE amongst patients undergoing NACT, whether there was an association with survival, and examine risk factors associated with the development of VTE.
Study Design: This was a retrospective cohort study of patients diagnosed with ovarian, fallopian tube and primary peritoneal cancer receiving neoadjuvant chemotherapy betweenApril 2011 and April 2022 at a gynaecological cancer centre in England.
Unlabelled: "Single Model initial-condition Large Ensembles" (SMILEs) conducted with Earth system models have transformed our ability to quantify internal climate variability and forced climate change at local and regional scales. An important consideration in their experimental design is the choice of initialization procedure as this influences the duration of initial-condition memory, with implications for interpreting the temporal evolution of both the ensemble-mean and ensemble-spread. Here we leverage the strategic design of the 100-member Community Earth System Model version 2 (CESM2) SMILE to investigate the dependence of ensemble spread on the method of initialization (micro- vs.
View Article and Find Full Text PDFPLoS Negl Trop Dis
December 2024
Institute of Mathematics and Computer Science, University of São Paulo, São Carlos, SP, Brazil.
Measures to curb the spread of SARS-CoV-2 impacted not only COVID-19 dynamics, but also other infectious diseases, such as dengue in Brazil. The COVID-19 pandemic disrupted not only transmission dynamics due to changes in mobility patterns, but also several aspects of surveillance, such as care seeking behavior and clinical capacity. However, we lack a clear understanding of the overall impact on dengue in different parts of Brazil and the contribution of individual causal drivers.
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