Objective: To document the natural history of vestibular schwannomas treated conservatively, and to find if there are any predictive factors for growth and need for active intervention.
Design: A retrospective review of patient notes and radiology, mostly MRIs.
Subjects: Eighty-eight patients managed conservatively for unilateral vestibular schwannoma and that have had at least two radiological investigations.
Outcome Measures: Change in tumour size over time was evaluated. Linear and logistic regression, respectively, were used to determine which factors (of age, size at diagnosis, audiology at presentation, length of follow-up or growth within first year of follow-up) would predict overall growth and active intervention. Characteristics of those that required active intervention is also demonstrated.
Results: Of the 88 patients, the average size of schwannoma at diagnosis was 10.88 mm. The mean length of radiological follow-up was 3.65 years. 51.1% of schwannomas grew, 12.5% shrank and 36.4% remained the same size. The mean rate of growth was 1.24 mm per year. 25.0% failed conservative treatment, with 19 patients having stereotactic radiosurgery and three undergoing microsurgery. Only growth in the first year of follow-up was found to significantly predict total growth. Size at diagnosis and growth in first year of follow-up were significantly found to predict active intervention.
Conclusions: There remains a place for conservative treatment in those with small tumours, the elderly and those with significant co-morbidities. Growth in the first year of follow-up should be considered in determining whether to treat actively or not.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/02688690903272634 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Residual effect of vermicompost and preceding groundnut on soil fertility and associated Striga density under sorghum cropping in Eastern Ethiopia.
PLoS One
March 2025
Alliance of Biodiversity International and CIAT, ILRI, Addis Ababa, Ethiopia.
Depletion of soil organic matter was found to be the primary biophysical factor causing declining per capita food production in sub-Saharan Africa. The magnitude of this problem was exacerbated by moisture-stress and imbalanced fertilizer application that caused Striga weed infestation. To address such confounded issues, two-year field experiments were conducted to evaluate the effect of residual vermicompost and preceding groundnut on soil fertility, sorghum yield, and Striga density.
View Article and Find Full Text PDFCreating a Framework for Minimizing Opioid Consumption after Office Based Surgery.
Curr Pain Headache Rep
March 2025
Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
Purpose Of Review: Herein we review recent trends in opioid prescribing, the rise in office-based surgeries, and propose a framework to minimize opioid consumption following such procedures.
Recent Findings: Outpatient surgical procedures are increasing year over year in the United States. This observed increase is expected to continue due to the financial incentives to perform outpatient procedures.
Maternal Inflammatory Proteins in Pregnancy and Neurodevelopmental Disorders at Age 10 Years.
JAMA Psychiatry
March 2025
Center for Neuropsychiatric Schizophrenia Research (CNSR& Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.
Importance: Maternal inflammation during pregnancy has been associated with an increased risk of neurodevelopmental disorders (NDDs), such as attention-deficit/hyperactivity disorder (ADHD) and autism, and cognitive deficits in early childhood. However, little is known about the contributions of a wider range of inflammatory proteins to this risk.
Objective: To determine whether maternal inflammatory proteins during pregnancy are associated with the risk of NDDs and executive functions (EF) in middle childhood and to identify protein patterns associated with NDDs and EF.
Establishment and Its Utility of a Patient-Derived Cell Xenografts (PDCX) Model with Cryopreserved Cancer Cells from Human Tumor.
Cells
February 2025
Department of Pathology, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea.
Patient-derived xenograft (PDX) models are powerful tools in cancer research, offering an accurate platform for evaluating cancer treatment efficacy and predicting responsiveness. However, these models necessitate surgical techniques for tumor tissue transplantation and face challenges with non-uniform tumor growth among animals. To address these issues, we attempted to develop a new PDX modeling method using high-grade serous ovarian cancer (HGSC), a fatal disease with a 5-year survival rate of 29%, which requires personalized research due to its morphological, genetic, and molecular heterogeneities.
View Article and Find Full Text PDFAssociations between social-network characteristics and postpartum health behaviors and weight among a sample of women who were overweight/obese pre-pregnancy.
Womens Health (Lond)
March 2025
Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.
Background: Retention of weight postpartum increases risk for long-term morbidity, including cardiometabolic disease. Although retained weight postpartum is a complex problem, interventions generally address individual diet and activity behaviors.
Objectives: We investigated the impact of social-network factors on postpartum health behaviors and weight.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!