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PilY1 regulates the dynamic architecture of the type IV pilus machine in Pseudomonas aeruginosa.
Nat Commun
October 2024
Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, 06536, USA.
Type IV pili (T4P) produced by the pathogen Pseudomonas aeruginosa play a pivotal role in adhesion, surface motility, biofilm formation, and infection in humans. Despite the significance of T4P as a potential therapeutic target, key details of their dynamic assembly and underlying molecular mechanisms of pilus extension and retraction remain elusive, primarily due to challenges in isolating intact T4P machines from the bacterial cell envelope. Here, we combine cryo-electron tomography with subtomogram averaging and integrative modelling to resolve in-situ architectural details of the dynamic T4P machine in P.
View Article and Find Full Text PDFTBC1D15 deficiency protects against doxorubicin cardiotoxicity inhibiting DNA-PKcs cytosolic retention and DNA damage.
Acta Pharm Sin B
December 2023
Department of Cardiology and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Clinical application of doxorubicin (DOX) is heavily hindered by DOX cardiotoxicity. Several theories were postulated for DOX cardiotoxicity including DNA damage and DNA damage response (DDR), although the mechanism(s) involved remains to be elucidated. This study evaluated the potential role of TBC domain family member 15 (TBC1D15) in DOX cardiotoxicity.
View Article and Find Full Text PDF'Five minutes earlier, you were giving hope': Reflections from interviews with doctors conducting assessments for South Africa's childhood disability Care Dependency Grant.
Wellcome Open Res
November 2022
Psychology Department, Stellenbosch University, Stellenbosch, Western Cape, 7600, South Africa.
In South Africa, medical doctors functionally decide whether a primary caregiver can access state-funded social assistance cash transfers ('social grants') for the care of their disabled child. In this paper, we unpack the subjective experiences of one group of doctors in the country's Western Cape province who are involved in conducting assessments for the care dependency grant, designed to support the cost of disabled children's specific needs. Individual in-depth interviews were conducted with five paediatric doctors who practice at three Cape Town public sector hospitals and regularly conduct assessments for the care dependency grant.
View Article and Find Full Text PDFLanguage Assessment for Immigration: A Review of Validation Research Over the Last Two Decades.
Front Psychol
November 2021
Department of English, University of Macau, Macau, China.
It is not uncommon for immigration-seekers to be actively involved in taking various language tests for immigration purposes. Given the large-scale and high-stakes nature those language tests possess, the validity issues (e.g.
View Article and Find Full Text PDFImpact of the gate-keeping policies of China's primary healthcare model on the future burden of tuberculosis in China: a protocol for a mathematical modelling study.
BMJ Open
August 2021
Department of Medical Statistics, School of Public Health, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Introduction: In the past three decades, China has made great strides in the prevention and treatment of tuberculosis (TB). However, the TB burden remains high. In 2019, China accounted for 8.
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