[Therapeutic effect of mineral water of the Belokurikha spa resort on the level of antinuclear antibodies and chromosomal aberrations in synovial cells of patients with osteoarthrosis].

The objective of this study was chromosomal analysis and measurement of anti-nuclear antibody level in synovial cells of 28 patients aged between 35 and 50 years with knee joint osteoarthrosis before and after radon therapy at an equivalent doe of 280 mSv per treatment course. It was shown that the presence of osteoarthrosis was associated with a rise in the number of synoviocytes characterized by cytogenetic defects in the form of various chromosomal aberrations the frequency of which positively correlated with the number of anti-nuclear antibodies. Radon therapy brought about a decreases in the titers of antinuclear antibodies in synovial cells and the number of chromosomal aberrations in their nuclear apparatus. These changes were accompanied by the enhancement of mitotic activity of synoviocytes, stimulation of protein synthesis in these cells, and activation of proliferative processes in the synovial medium of the joints.