Kingella kingae can cause invasive pediatric infections and outbreaks of osteomyelitis/septic arthritis in daycare facilities have been described. This is the first reported public health investigation prompted by a case of K. kingae endocarditis in an infant attending a daycare facility. A concurrent case of osteomyelitis was identified. Screening of daycare contacts revealed a low rate of colonization before antibiotic prophylaxis.
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Structural and functional significance of two conserved lysine residues in acylated sites of Kingella kingae RtxA cytotoxin.
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Institute of Microbiology of the Czech Academy of Sciences, v.v.i., 142 20 Prague, Czech Republic. Electronic address:
Kingella kingae, an emerging pediatric pathogen, secretes the pore-forming toxin RtxA, which has been implicated in the development of various invasive infections. RtxA is synthesized as a protoxin (proRtxA), which gains its biological activity by fatty acylation of two lysine residues (K558 and K689) by the acyltransferase RtxC. The low acylation level of RtxA at K558 (2-23%) suggests that the complete acylation at K689 is crucial for toxin activity.
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Pediatric Orthopaedic Unit, Pediatric Surgery Service, Geneva University Hospitals, Geneva, Switzerland.
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