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Oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis: Results from a randomized, double-blind, placebo-controlled study.
Contemp Clin Trials Commun
February 2025
Department of Nursing, School of Nursing, University of Extremadura, Mérida, Spain.
Osteoarthritis (OA) is a major source of chronic pain and disability, representing a significant global health concern that affects 10-15 % of individuals aged over 60, with a higher prevalence among females than males. This investigation aimed to evaluate the impact of a dietary supplement containing collagen peptides (MW 1-3 kDa) on knee OA symptoms and inflammatory biomarkers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Adults aged 30-81 years (50 % female) with grade II or III OA and a minimum pain score of 40 on the 0 to 100 visual analogue scale (VAS) were enrolled.
View Article and Find Full Text PDFComparative Analysis of CXCR5 Circulating DNA Methylation Levels in Autoimmune Rheumatic Diseases.
Immun Inflamm Dis
January 2025
Department of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Objective: To assess CXC chemokine receptor 5 (CXCR5) circulating DNA methylation differences in autoimmune rheumatic diseases and their relation with clinical features.
Methods: Targeted methylation sequencing was performed using peripheral blood from 164 rheumatoid arthritis (RA), 30 systemic lupus erythematosus (SLE), 30 ankylosing spondylitis (AS), 30 psoriatic arthritis (PsA), 24 Sjögren's syndrome (SS) patients, and 30 healthy controls (HC).
Results: Significant differences in CXCR5 cg19599951 methylation were found between RA and HC, as well as AS and SLE.
Estimation of Equivalent Series Resistance (ESR) of Supercapacitors Using Charging/Discharging Kinetics.
ChemistryOpen
January 2025
Electronics Engineering College, Ninevah University, North east side of Mosul University - Stadium Entrance Gate - Mosul University, Mosul, Iraq.
One of the key parameters that affects efficiency, power density and performance of a supercapacitor (SC) is the equivalent series resistance (ESR). In this study we propose a method to estimate ESR from the charging kinetics which has practical applications. Therefore, to study the ESR of the SC we must look at the different factors that affect this resistance.
View Article and Find Full Text PDFThree-dimensional whole-body imaging of the bioreduction and clearance of nitroxide probes in the thoracic and abdominal regions of mice using a compact and mobile electron paramagnetic resonance imager.
Magn Reson Med
January 2025
Advanced Research Promotion Center, Health Sciences University of Hokkaido, Ishikari, Japan.
Purpose: Redox homeostasis plays a key role in regulating the overall health and development of organisms. This study aimed to develop a compact and mobile continuous-wave (CW) electron paramagnetic resonance (EPR) imager to facilitate stable, highly sensitive fast three-dimensional (3D) whole-body imaging of nitroxide-infused mice.
Methods: A multiturn loop gap resonator with a diameter of 30 mm and length of 35 mm was designed for whole-body EPR imaging.
Clinical and Hematological Manifestations of Systemic Lupus Erythematosus at Initial Presentation in a Tertiary Healthcare Center.
Cureus
December 2024
Department of Dermatology, Venereology and Leprosy, Great Eastern Medical School & Hospital, Srikakulam, IND.
Background Systemic Lupus Erythematosus (SLE) is a multifaceted autoimmune disorder with diverse clinical presentations, among which hematological abnormalities often serve as early and critical indicators of disease. These manifestations, including anemia, leukopenia, lymphopenia, and thrombocytopenia, correlate with disease activity and provide essential diagnostic insights, particularly in resource-limited settings where access to advanced diagnostic tools may be constrained. This study emphasizes the significance of hematological findings that frequently appear at the initial presentation of SLE.
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