AI Article Synopsis
- Peripheral blood stem cell transplantation (PBSCT) is an alternative to bone marrow transplantation (BMT), but the regulatory T cell (Treg) content in both types has not been thoroughly compared before.
- The study reveals that Treg frequencies are significantly lower in PBSC compared to BM transplants, with most Tregs in PBSC transplants displaying a phenotype associated with weak suppressive abilities.
- Factors like G-CSF administration and leukapheresis contribute to the reduction of functional Tregs, which may help explain the increased risk of graft-versus-host disease (GVHD) seen in PBSCT patients despite a higher infusion of T cells.
Article Abstract
Peripheral blood stem cell transplantation (PBSCT) is an alternative to bone marrow transplantation (BMT). Although CD4(+)CD25(+)CD127(lo) regulatory T cells (Tregs) have been shown to play important roles in the control of T cell reactivity, the Treg contents of both graft types have not been analyzed comparatively to date. We report herein that Treg frequencies are significantly reduced in PBSC compared to BM transplants. Furthermore, most Tregs from PBSC transplants are CD62L(lo), a phenotype reported to have poor suppressor activity. Both granulocyte-colony stimulating factor (G-CSF) administration and leukapheresis were found to contribute to the loss of CD62L(+) Tregs. Although higher T cell numbers are infused in PBSCT than in BMT, it is possible that the reduced Treg content of PBSC transplants may represent 1 factor contributing to the higher risk of GVHD reported after PBSCT.
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| http://dx.doi.org/10.1016/j.bbmt.2009.10.027 | DOI Listing |
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