Bechet's disease (BD) is an inflammatory, multi systemic disease with spontaneous remissions and relapses similar to various autoimmune diseases. BD leads to organ damage, including the eyes, skin, joints, etc., which produces various clinical manifestations. The central histopathologic characteristic is systemic vasculitis with perivascular inflammatory infiltrates. The etiopathogenesis is unknown, although immunological abnormalities, possibly induced by susceptible microbiological pathogens, have been postulated.
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Juvenile Behçet syndrome: a contemporary view and differential diagnosis in pediatric practice.
Curr Opin Rheumatol
January 2025
Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa.
Purpose Of Review: This review aims to provide a comprehensive and contemporary overview of juvenile Behçet syndrome (jBS), highlighting its clinical manifestations, diagnostic challenges, and treatment strategies.
Recent Findings: Behçet syndrome, with its intricate etiopathogenesis and diverse clinical phenotypes, is more aptly classified as a syndrome than a single disease. Its heterogeneous nature requires a broad diagnostic approach and sophisticated differential diagnosis capabilities.
Behçet's Syndrome With Multiple Bilateral Pulmonary Aneurysms Associated With Endomyocardial Fibrosis Presented With Pulmonary Emboli: A Case Report.
Cureus
August 2024
Department of Diagnostic Radiology, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawwarah, SAU.
Behçet's syndrome (BS) is a rare chronic multisystemic inflammatory disorder of unknown etiopathogenesis. BS is classified as a vasculitis of variable vessel size, which can manifest in both arterial and venous blood vessels. BS commonly presents with mucocutaneous and ocular manifestations.
View Article and Find Full Text PDFThe role of fatty acids in patients with Behçet's disease and their association with thrombosis.
Lipids
September 2024
Division of Biochemistry, Selcuk University Faculty of Medicine, Konya, Turkey.
Behçet's disease (BD) is a systemic disease with unknown etiopathogenesis and varying disease presentations. Fatty acids (FA) are essential biological compounds that are involved in complex metabolic pathways. They may contribute to inflammation and endothelial dysfunction by participating in many signaling pathways.
View Article and Find Full Text PDFEULAR study group on 'MHC-I-opathy': identifying disease-overarching mechanisms across disciplines and borders.
Ann Rheum Dis
July 2023
Amsterdam Rheumatology and immunology Center (ARC)| Reade, Amsterdam, The Netherlands
Article Synopsis
- The 'MHC-I-opathy' concept refers to a group of inflammatory diseases linked to the major histocompatibility complex class I, with recognized conditions including spondyloarthritis and psoriasis, all associated with specific genetic variants.
- There is a significant challenge in understanding and treating these disorders due to differences in patient symptoms and insufficient research on the MHC-I pathway.
- The text advocates for a collaborative approach involving diverse medical and research disciplines to standardize disease definitions, explore genetic factors, and improve therapeutic strategies, ultimately aiming to enhance patient care.
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Immunol Res
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Department of Biophysics, Faculty of Medicine, Pamukkale University, 20070, Denizli, Turkey.
Although the etiopathogenesis of Behçet's disease is not known, studies conducted in different populations show that it is a multifactorial disease that is thought to develop as a result of the interaction of environmental and genetic factors. IL-17 is thought to induce the neutrophilic inflammation and the tissue damage mediated by immune response in patients. Polymorphisms in the gene region encoding IL-17 and IL-17R molecules may play a critical role in the pathogenesis of the disease and contribute to the elucidation of disease mechanism.
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