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Correlation Between DCAMKL-1 Protein Expression and K-ras Gene Mutation in Colorectal Cancer.
Cancer Manag Res
January 2024
Department of Pathology, Guizhou Provincial People's Hospital, Guiyang, 550002, People's Republic of China.
Aim: To investigate the correlation between doublecortin and CaM kinase-like-1 (DCAMKL-1) protein expression, K-ras gene mutation, and their impact on patient prognosis in colorectal cancer (CRC).
Methods: Immunohistochemistry was used to detect the expression of DCAMKL-1 protein in 60 cases of colorectal adenoma, 82 cases of CRC (including 65 cases of lymph node metastasis) and paraffin-embedded paracancerous intestinal mucosal tissue. K-ras gene mutations in primary CRC lesions were detected using an amplification-refractory mutation system and fluorescent polymerase chain reaction.
GSK-3β inhibitor 6-bromo-indirubin-3'-oxime promotes both adhesive activity and drug resistance in colorectal cancer cells.
Int J Oncol
December 2017
Department of General Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.
Multi-targets inhibitor 6-bromo-indirubin-3'-oxime (BIO) has diverse biological effects on cancer cells. The key component of the β-catenin destruction complex glycogen synthase kinase 3β (GSK-3β), one of the major target for BIO, polyubiquitination and degradation of the main oncoprotein β-catenin in colorectal cancer (CRC). In the present study, we evaluated the effect of BIO on drug resistance and biological properties of CRC cells.
View Article and Find Full Text PDFTankyrase 1 inhibitior XAV939 increases chemosensitivity in colon cancer cell lines via inhibition of the Wnt signaling pathway.
Int J Oncol
April 2016
Department of Pathology, Qingyuan People's Hospital, Jinan University, Qingyuan, Guangdong 511518, P.R. China.
Aberrant Wnt signaling pathway is associated with a wide array of tumor types and plays an important role in the drug resistance of cancer stem cells (CSCs). To explore the effects and mechanism of WNT signaling pathway inhibitor XAV939 on drug resistance in colon cancer cells, the colon cancer cells SW480 and SW620 were treated with 5-fluorouracil (5-FU)/cisplatin (DDP) alone or combined with XAV939. Cell cycle distribution, apoptosis level and the percentage of CD133+ cells were detected by flow cytometry.
View Article and Find Full Text PDF[Investigation of doublecortin and calcium/calmodulin-dependent protein kinase-like-1-expressing cells in the mouse colon with acute and chronic mucosal injury].
Sichuan Da Xue Xue Bao Yi Xue Ban
November 2012
Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective: To identify the expression of Doublecortin and calcium/calmodulin-dependent protein kinase-like-1-expressing cells (DCAMKL-1-expressing cells) in the colon epithelium and to analyze their deviation in dextran sulfate sodium (DSS) induced colitis and colitis associated cancer.
Methods: A total of 60 healthy female C57 BL/6J mice were used, 40 for the DSS induced colitis model group and 20 for colitis associated cancer model group. In the former group, mice were sacrificed at day 7 after DSS administration (B group), 3 days (C group) and 7 days (D group) after DSS withdraw, separately.
Expression of LGR-5, MSI-1 and DCAMKL-1, putative stem cell markers, in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis: correlation with nuclear β-catenin.
BMC Cancer
February 2013
Department of Pharmacology, University of Florence, 6 Viale Pieraccini, 50139, Florence, Italy.
Background: Colon cancer stem cells may drive carcinogenesis and account for chemotherapeutic failure. Although many markers for these cells have been proposed, there is no complete agreement regarding them, nor has their presence in the early phases of carcinogenesis been characterized in depth.
Methods: The expression of the putative markers LGR-5 (leucine-rich-repeat-containing G-protein-coupled receptor 5), MSI-1 (Musashi-1) and DCAMKL-1 (doublecortin and calcium/calmodulin-dependent protein kinase-like-1) was studied in normal colon mucosa (NM), in the precancerous lesions Mucin Depleted Foci (MDF) and in macroscopic tumours (adenomas) of 1,2-dimethylhydrazine-treated rats.
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