Objective: To investigate the effects and of toxicity mechanism of 2,2',4,4'-TETRABDE (BDE-47) on TT3, TT4 and TSH in C57BL/6 mice.
Methods: C57BL/6 mice were divided randomly into 4 groups, and given with corn oil (control group) and 1 micromol/(kg x d), 10 micromol/(kg x day) and 100 micromol/(kg x day) BDE-47 for 4 days through intraperitoneal injection respectively. After collecting the bloods, livers and thyroids, the T3, T4 and TSH levels of serum were detected by electro chemiluminescenc (ECLI), thyroid peroxidase (TPO) activities in thyroid by guaiacol method and type-I deiodinase (DI) in liver by CHOPRA method.
Results: Compared with the control group, the level of TT4 decreased significantly in the three BDE-47 dose groups, TT3 in the medium and high dose groups decreased significantly, and the activities of DI increased in the medium and high dose groups significantly (P < 0.05), whereas TSH level in serum and activity of TPO in thyroid in the three dose groups weren't statistically significant comparing with control group.
Conclusion: BDE-47 could affect the homeostasis of thyroid hormone system, and activity of type-I deiodinase (DI) in liver being changed might be the one of toxicity mechanisms.
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