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Analysis of the clinical value of serum MMP-9 and VEGF expression levels in the prenatal diagnosis of patients with aggressive placenta previa.
J Matern Fetal Neonatal Med
December 2025
Department of Obstetrics and Gynecology, The First People's Hospital of Tianmen City, Tianmen City, Hubei Province, China.
Objective: To investigate the diagnostic efficacy and detection value of matrix metalloproteinase-9 (MMP-9) and VEGF in menacing pernicious placenta previa (PPP).
Method: Among all the cases of PPP, a critical condition within the Placenta Accreta Spectrum (PAS) caused by aberrant implantation of the placenta in the uterine wall, which were analyzed between April 2021 and March 2023, there were sixty-three cases. The control group consisted of those sixty-three women who had a normal placenta.
SARS-CoV-2 Placentitis: A Review of Pathologic Findings and Discussion of Differential Diagnosis.
Arch Pathol Lab Med
March 2025
From the Department of Pathology, University of Michigan, Ann Arbor.
Context.—: Maternal SARS-CoV-2 infection has been associated with increased adverse events in the mother, as well as increased stillbirths (11.5 per 1000), spontaneous abortions, and premature delivery.
View Article and Find Full Text PDFThe inhibition of placental mTOR signaling leads to fetal growth restriction with abnormal glucose metabolism in different anatomical regions of placentas.
Placenta
March 2025
Department of Obstetrics and Gynecology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi Province, China. Electronic address:
Introduction: Fetal growth restriction (FGR) is a common pregnancy complication with significant impact on obstetric and birth outcomes. Increasing evidence shows that the inhibition of placental mechanistic target of rapamycin (mTOR) signaling is closely related to FGR. However, the pathogenesis of FGR is not fully consistent presently, which is subject to the methodological divergence.
View Article and Find Full Text PDFReview: Placental physiology and fetal programming in ruminants under heat stress.
Biol Reprod
March 2025
Department of Animal Sciences, University of Florida, Gainesville 31608, USA.
The placenta plays a crucial role in transferring nutrients and oxygen between the dam and fetus during pregnancy. It is highly influenced by environmental conditions, especially stressors such as heat and nutritional deficiencies, which can significantly impact the fetus's long-term health and development. Cattle, especially dairy cows, commonly experience stress during late gestation, which can lead to changes in behavior and physiology, affecting both subsequent milk production and fetal development.
View Article and Find Full Text PDFInsulin resistance-induced mitochondrial dysfunction and pyroptosis in trophoblasts: protective role of metformin.
BMC Pregnancy Childbirth
March 2025
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Background: Gestational diabetes mellitus (GDM) affects up to 14% of pregnancies globally, with insulin resistance (IR) playing a critical but often underappreciated role in its pathogenesis. Yet the specific impact of insulin at IR levels on mitochondrial function and pyroptosis in first-trimester trophoblasts remains unclear. Metformin use in GDM pregnancies is rising, but its impact on placental mitochondrial function is uncertain.
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