Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three ent-kaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862477PMC
http://dx.doi.org/10.1021/np900572gDOI Listing

Publication Analysis

Top Keywords

stem bark
8
bark mitrephora
8
mitrephora glabra
8
bioactive constituents
4
constituents stem
4
glabra bioactivity-guided
4
bioactivity-guided fractionation
4
fractionation stem
4
glabra yielded
4
yielded compounds
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!