An attempt has been made to analyze the factors involved in the development and localization of the dermal pneumococcic lesion in the rabbit. The character and quantity of the edema fluid which forms during the early phases of the lesion are intimately concerned in its development and spread. It contains an antithrombic substance, probably derived from the pneumococci, and delayed coagulation probably facilitates its movement through the tissue. The direction of spread in the skin is determined by gravity, and the fluid finally localizes in the more dependent regions. The distance that the pneumococcic lesion travels and the local tissue characters have much to do with the amount of fluid that accumulates. Studies are also reported of some factors which alter the rate of spread of the edema fluid. An acceleration in rate occurs when H. influenzae is used as an associative infective agent with the Pneumococcus.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180304 | PMC |
http://dx.doi.org/10.1084/jem.54.6.847 | DOI Listing |
The capacity of the serum of rabbits following intradermal pneumococcus infections to precipitate in the presence of pneumococcus C polysaccharide has been studied during the resultant periods of active infection and during recovery. In rabbits infected with Type I, III, or VIII pneumococci, large hemorrhagic lesions are produced which frequently bring about death of the animals after a febrile illness of 3 to 4 days. Repeated precipitation tests with the sera of these animals have been uniformly and consistently negative, not only during the acute illness but in the recovery period as well.
View Article and Find Full Text PDFAn attempt has been made to analyze the factors involved in the development and localization of the dermal pneumococcic lesion in the rabbit. The character and quantity of the edema fluid which forms during the early phases of the lesion are intimately concerned in its development and spread. It contains an antithrombic substance, probably derived from the pneumococci, and delayed coagulation probably facilitates its movement through the tissue.
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