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Colistin antibacterial activity, clinical effectiveness, and mechanisms of intrinsic and acquired resistance.
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January 2025
Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
Following a period of disuse owing to the emergence of multidrug-resistant Gram-negative bacteria, colistin has regained global attention as an antibiotic of last resort. The resurgence in its utilization has led to a concurrent increase in acquired resistance, presenting a significant challenge in clinical treatment. Predominantly, resistance mechanisms involve alterations in the lipid A component of the lipopolysaccharide (LPS) structure.
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Matrix Biol
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Department of Pharmacology & Immunology, Proteomics Center, Medical University of South Carolina, Charleston, SC. Electronic address:
Collagen stroma interactions within the extracellular microenvironment of breast tissue play a significant role in breast cancer, including risk, progression, and outcomes. Hydroxylation of proline (HYP) is a common post-translational modification directly linked to breast cancer survival and progression. Changes in HYP status lead to alterations in epithelial cell signaling, extracellular matrix remodeling, and immune cell recruitment.
View Article and Find Full Text PDFFluorescence-enhanced detection of sulfide ions through tuning the structure-activity relationship of gold nanoclusters.
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Hebei Key Lab of Power Plant Flue Gas Multi-Pollutants Control, Department of Environmental Science and Engineering, North China Electric Power University, Baoding 071003, China; Guangdong Provincial Key Laboratory for Green Agricultural Production and Intelligent Equipment, School of Environmental Science and Engineering, Guangdong University of Petrochemical Technology, Maoming 525000, China. Electronic address:
The concentration of S is a vital environmental indicator for evaluating the quality of source water, surface water, and wastewater, and it has a significant impact on biological systems, particularly human health. Therefore, it is crucial to detect S selectively and sensitively. In this study, we developed a simple and rapid one-pot method to prepare a gold nanocluster (BSA-AuNCs) probe for fluorescence-enhanced detection of S toxemia and analyzed the morphological characteristics of BSA-AuNCs and its complex with S using various characterization techniques.
View Article and Find Full Text PDFDiscarded floral foam as a source for green preparation of sustainable adsorbent for quick and efficient removal of phenoxyacetic acid herbicides from waters.
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College of the Environment and Ecology, Xiamen University, Xiamen 361005, China; Fujian Provincial Key Laboratory for Coastal Ecology and Environmental Studies, Xiamen University, Xiamen 361005, China. Electronic address:
Due to the high toxicity and increasing consumption, efficient removal of phenoxyacetic acid herbicides (PAAHs) from water is imperative. In current study, a new adsorbent was prepared by modifying porous carbon derived from disused floral foam with chitosan (CS) (ACFC). Density functional theory (DFT) calculation uncovered that the amino and hydroxyl groups in the introduced CS played a critical role in the efficient adsorption of ACFC towards PAAHs.
View Article and Find Full Text PDFCharacterization of a cell-adapted completely attenuated genotype GIIa porcine epidemic diarrhea virus strain.
Virology
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State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China; Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, 730046, China. Electronic address:
Porcine epidemic diarrhea virus (PEDV) has caused significant harm to the global pig industry since its discovery. In this study, a highly pathogenic strain of GIIa PEDV CH/HBXT/2018, isolated previously, was continuously passaged in Vero cells up to passage (P)240, resulting in a completely attenuated virus. The proliferation characteristics of different passages of the strain in Vero cells, pathogenicity in newborn piglets, and mutations in S gene sequence indicated that as the passage number increased, the replication efficiency of PEDV in Vero cells gradually improved, with a more pronounced cytopathic effect.
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