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Autoinducer-2 enhances the defense of against oxidative stress and DNA damage by modulation of c-di-GMP signaling via a two-component system.
mBio
January 2025
State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China.
As a universal language across the bacterial kingdom, the quorum sensing signal autoinducer-2 (AI-2) can coordinate many bacterial group behaviors. However, unknown AI-2 receptors in bacteria may be more than what has been discovered so far, and there are still many unknown functions for this signal waiting to be explored. Here, we have identified a membrane-bound histidine kinase of the pathogenic bacterium , AsrK, as a receptor that specifically detects AI-2 under low boron conditions.
View Article and Find Full Text PDFImpact of prolonged surgical waiting time on cancer-specific mortality in stage I-II pancreatic ductal adenocarcinoma patients who received radical resection.
J Gastrointest Oncol
December 2024
Department of Gastroenterology, Yijishan Hospital of Wannan Medical College, Wuhu, China.
Background: The impact of prolonged surgical waiting time (SWT) on the prognosis of pancreatic ductal adenocarcinoma (PDAC) remains controversial. This study aimed to explore the impact of prolonged SWT on PDAC-specific mortality (PSM).
Methods: The data of patients with stage I-II primary PDAC who received radical resection were obtained from the Surveillance, Epidemiology, and End Results database.
Patient perspectives on stress after ICU and a short primary care based psychological intervention - results from a qualitative sub‑study of the PICTURE trial.
BMC Prim Care
January 2025
Institute of General Practice and Family Medicine, University Hospital, LMU Munich, Munich, Germany.
Background: Approximately 20-25% of patients who survive medical treatment at an intensive care unit (ICU) develop post-traumatic stress symptoms. There is currently a gap in follow-up care for them. As part of the PICTURE study, general practitioners (GPs) carried out a brief interview-based intervention.
View Article and Find Full Text PDFDigital Meditation to Target Employee Stress: A Randomized Clinical Trial.
JAMA Netw Open
January 2025
Department of Psychiatry and Behavioral Sciences, University of California San Francisco.
Importance: Mindfulness meditation may improve well-being among employees; however, effects of digital meditation programs are poorly understood.
Objective: To evaluate the effects of digital meditation vs a waiting list condition on general and work-specific stress and whether greater engagement in the intervention moderates these effects.
Design, Setting, And Participants: This randomized clinical trial included a volunteer sample of adults (aged ≥18 years) employed at a large academic medical center who reported mild to moderate stress, had regular access to a web-connected device, and were fluent in English.
How much time to figure out how to get where? Route planning and subjective stress under time pressure.
PLoS One
January 2025
Department of Psychology, Tufts University, Medford, Massachusetts, United States of America.
From a daily commute to military operations in hostile territory and natural disaster responses, people frequently move from place to place. Cognition (e.g.
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