Site-selective scission of human genome by artificial restriction DNA cutter.

Chem Commun (Camb)

Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, 153-8904 Tokyo, Japan.

Published: November 2009

By using an artificial restriction DNA cutter which is composed of Ce(iv)/EDTA and two pseudo-complementary peptide nucleic acid strands (pcPNAs), only one target site in the whole genome of human beings (one site in the X chromosome) was selectively hydrolyzed.

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Source
http://dx.doi.org/10.1039/b911208aDOI Listing

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