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Quercetin-Driven Akkermansia Muciniphila Alleviates Obesity by Modulating Bile Acid Metabolism via an ILA/mA/CYP8B1 Signaling.
Adv Sci (Weinh)
January 2025
College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.
Global health is increasingly challenged by the growing prevalence of obesity and its associated complications. Quercetin, one of the most important dietary flavonoids, is being explored as an effective therapy for obesity with its mechanism remains understudied. Here in this study, it is demonstrated that quercetin intervention significantly reverses obesity-related phenotypes through reshaping the overall structure of microbiota, especially boosting colonization of the beneficial gut commensal Akkermansia muciniphila (A.
View Article and Find Full Text PDF[Use of secondary raw materials of the wine industry for the production of a functional fermented milk product].
Vopr Pitan
January 2025
M.G. Safronov Yakut Scientific Research Institute of A griculture - Division of Federal Research Centre "The Yakut Scientific Centre of the Siberian Branch of the Russian Academy of Sciences", 677001, Yakutsk, The Republic of Sakha (Yakutia), Russian Federation.
The development of new technologies and the production of functional food based on secondary raw materials is an urgent problem that requires careful study. of the research was to study the chemical composition of the powder from the pomace of Riesling and Cabernet Sauvignon grape varieties, as well as the possibility of using this powder for the preparation of functional yogurt. .
View Article and Find Full Text PDF[Effect of separate and combined intake of rutin and hesperidin on the activity and gene expression of cytochrome P450 isoforms 1A and 3A in rat liver].
Vopr Pitan
January 2025
Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.
The main molecular mechanisms of the protective effect of minor bioactive compounds (BAC) of food, including rutin and hesperidin, along with antiradical and antioxidant activity, include their interaction with transcription factors modulating the functional state of the organism defense systems, one of which is the system of xenobiotic metabolizing enzymes. However, the data on their combined action are limited. of the research was to study the effect of rutin and hesperidin on the activity and gene expression of cytochrome P450 isoforms 1A and 3A (CYP1A1, CYP1A2, CYP3A) in rat liver at their separate and combined intake.
View Article and Find Full Text PDF[Assessment of basketball players' nutrition in dynamics].
Vopr Pitan
January 2025
Federal Research Centre for Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.
Basketball is one of the most popular sports in the world, with competitions held at national, international, continental and world levels, including the Olympic Games. Optimal nutrition plays a key role in sports performance and the implementation of recovery strategies, which determined the relevance of this study. of the research was to analyze the nutrition of basketball players in dynamics to determine the need to introduce specialized or dietary supplement into the diet.
View Article and Find Full Text PDF[Development of allergenic potential's assessment approaches of protein hydrolysates obtained from alternative food sources].
Vopr Pitan
January 2025
Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.
The investigation of the perspectives for the application of alternative protein sources in food production has allowed us to identify two main directions requiring comprehensive scientific support: firstly, the development of production and processing of food protein technologies to obtain food hydrolysates with a given composition and properties, and secondly, the assessment of the such product safety, including evaluation of their allergenic potential. Currently, within the second direction, research is being conducted to improve approaches to assessing the allergenic potential of innovative food, search for new in vitro and in vivo models and biomarkers to guarantee the safety of these products for consumers. of the study was to research the allergenic potential of the methanotrophic bacteria protein hydrolysates on the model of systemic anaphylaxis in rats and to formulate approaches to assessing the novel foods' safety.
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