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(NHC)CuH-catalyzed entry to allenes via propargylic carbonate S(N)2'-reductions. | LitMetric

(NHC)CuH-catalyzed entry to allenes via propargylic carbonate S(N)2'-reductions.

Org Lett

Organic Chemistry, Dortmund University of Technology, Otto-Hahn-Strasse 6, D-44227 Dortmund, Germany.

Published: November 2009

AI Article Synopsis

Article Abstract

The copper hydride-catalyzed S(N)2'-reduction of propargylic carbonates provides an efficient route to functionalized allenes. The method takes advantage of the stabilizing effect of NHC ligands on CuH and combines high reactivity and stereoselectivity with excellent tolerance toward reactive functionalities.

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Source
http://dx.doi.org/10.1021/ol901868mDOI Listing

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