Infection with hepatitis C virus (HCV) is a common global cause of chronic liver disease, which is also true in Saudi Arabia. HCV prevalence in Saudi Arabia varies in different provinces being highest in the Western and Southern provinces. Most of the studies among blood donors documented a decrease in HCV prevalence, probably due to increase awareness and improved socioeconomic status. Genotype 4 is the commonest genotype in Saudi patients infected with HCV which unfortunately is least likely to respond to the standard interferon therapy though recent studies using pegylated interferon demonstrated promising results. Liver transplantation for patients with end stage liver disease was started in 1994 but the cases currently done are still less than that required.
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