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Impact of Surgical Mask Placement Over High-Flow Nasal Cannula on Oxygenation Parameters in COVID-19 Patients Experiencing Hypoxemic Respiratory Failure.
Cureus
December 2024
Department of Emergency Medicine, MGM Medical College and Hospital, Navi Mumbai, IND.
Background: During the COVID-19 pandemic, managing respiratory failure in critically ill patients has presented significant challenges. A high-flow nasal cannula (HFNC) has been established as an effective respiratory support modality, offering heated, humidified oxygen at high flow rates. However, concerns persist regarding the potential for aerosol dispersion and the risk of viral transmission, particularly in COVID-19.
View Article and Find Full Text PDFOptimizing the hyperbaric chamber pressurization profile during standard hyperbaric oxygen therapy.
Undersea Hyperb Med
January 2025
King Hamad American Mission Hospital, A'ali, Kingdom of Bahrain.
Middle ear barotrauma (MEBT) is the most common complication in providing hyperbaric oxygen therapy (HBO). This study explored the impact of altering the shape of the time-pressure curve with the aim of reducing the occurrence of MEBT and optimizing the HBO experience during the pressurization process. Four distinct mathematically derived protocols-Constant Pressure Difference (CPD), Constant Volume Difference (CVD), Constant Ratio (CR), and Inverted Constant Ratio (ICR)-were investigated using computer simulations on a simple ear model.
View Article and Find Full Text PDFPsychometric assessment of scales used to evaluate sexual assault prevention programming in the United States Air Force.
PLoS One
January 2025
Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Background: Preventing sexual assault in the United States (U.S.) military is essential to safeguard the overall well-being of military personnel and support the military to function in alignment with its intended mission and objectives.
View Article and Find Full Text PDFGravity-Driven Membrane Filtration with Passive Hydraulic Fouling Control for Drinking Water Treatment: Demonstration of Long-Term Performance at Full Scale.
ACS ES T Water
January 2025
Department of Civil Engineering, The University of British Columbia, 6250 Applied Sciences Lane, Vancouver, British Columbia V6T 1Z4, Canada.
The present study evaluated the performance of a full-scale gravity-driven membrane filtration system with passive hydraulic fouling control (PGDMF) for drinking water treatment in a small community over a 3-year period. The PGDMF system consistently met the design flow and regulated water quality/performance parameters (i.e.
View Article and Find Full Text PDFChimeric antigen receptor macrophages (CAR-M) sensitize HER2+ solid tumors to PD1 blockade in pre-clinical models.
Nat Commun
January 2025
Carisma Therapeutics Inc, Philadelphia, PA, USA.
We previously developed human CAR macrophages (CAR-M) and demonstrated redirection of macrophage anti-tumor function leading to tumor control in immunodeficient xenograft models. Here, we develop clinically relevant fully immunocompetent syngeneic models to evaluate the potential for CAR-M to remodel the tumor microenvironment (TME), induce T cell anti-tumor immunity, and sensitize solid tumors to PD1/PDL1 checkpoint inhibition. In vivo, anti-HER2 CAR-M significantly reduce tumor burden, prolong survival, remodel the TME, increase intratumoral T cell and natural killer (NK) cell infiltration, and induce antigen spreading.
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