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Seroprevalence of Strongyloides stercoralis, human T-lymphotropic virus, and Chagas disease in the Peruvian Amazon: a cross-sectional study.
Rev Inst Med Trop Sao Paulo
December 2024
Hospital Universitario General Dr. Balmis, Departamento de Medicina Interna, Alicante, Spain.
Strongyloides stercoralis infections, human T-lymphotropic virus (HTLV) infections, and Chagas diseases occur throughout many regions of Central and South America, including Peru. This study aimed to evaluate the seroprevalence of S. stercoralis, HTLV, and Chagas disease in Iquitos (Peruvian Amazon) and the associated epidemiological conditions for S.
View Article and Find Full Text PDFBackground: Despite saving a vast number of lives through blood transfusions, transfusion-transmitted infections (TTIs) still threaten the lives of people needing blood transfusion. Hence, screening blood donors and reviewing the prevalence of TTIs amongst blood donors might show the impact of these infections among our people. The aim of this study was to evaluate the prevalence rates of transfusion-transmitted infections among blood donors in Makkah as foundation for providing harmless blood transfusion in Makkah, Saudi Arabia.
View Article and Find Full Text PDFDiagnostic Value of Anti-HTLV-1-Antibody Quantification in Cerebrospinal Fluid for HTLV-1-Associated Myelopathy.
Viruses
October 2024
Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki 216-8512, Japan.
Article Synopsis
- The study investigates the effectiveness of testing cerebrospinal fluid (CSF) for anti-HTLV-1 antibodies in diagnosing HTLV-1-associated myelopathy (HAM), highlighting the diagnostic accuracy of various test kits.
- It found that while CSF antibody levels were stable when refrigerated, they were affected by freeze-thaw cycles, leading to strong correlations in test results across different methods used on samples from 92 patients (69 with HAM, 23 carriers).
- The results showed high diagnostic performance for HAM, with five test kits achieving 100% sensitivity and varying specificity, suggesting that these tests combined with clinical evaluation can improve HAM diagnosis.
Therapeutic advances for the management of adult T cell leukemia: Where do we stand?
Leuk Res
December 2024
Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. Electronic address:
Article Synopsis
- - Adult T cell leukemia (ATL) is a serious blood cancer linked to HTLV-1 virus infection, with four subtypes that have varying effects on treatment response and prognosis.
- - While some subtypes benefit from antiretroviral therapy, others, like acute ATL, are more aggressive with poor outcomes and may become resistant to chemotherapy.
- - Newer treatment approaches, including targeted therapies and potential anti-viral strategies focusing on the Tax protein, show promise in improving ATL management, although allogeneic stem cell transplant remains the only curative option for a limited number of patients.
The prevalence of hepatitis B virus, human T-lymphotropic virus and human immunodeficiency virus in patients receiving blood transfusions in South Africa.
Vox Sang
November 2024
Transfusion Medicine and Technical services, South African National Blood Service, Johannesburg, South Africa.
Background And Objectives: South Africa has a high prevalence of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) and to a lesser extent human T-lymphotropic virus (HTLV). Each of these agents is transfusion-transmissible (TT) but deciding whether to implement preventive screening depends upon knowledge of background prevalence in transfused patients. We determined the prevalence of HIV, HBV and HTLV I/II among blood transfusion recipients in South African hospitals.
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