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Factors associated with mortality in thoracic trauma patients in Cameroon.
Heliyon
January 2025
Data Science Center for the Study of Surgery, Injury, and Equity in Africa (D-SINE-Africa), University of Buea, Cameroon.
Background: Thoracic trauma is the third most common cause of death after abdominal injury and head trauma in polytrauma patients. The identification of a patient at risk of thoracic trauma mortality is necessary to avoid delays that may lead to morbidity and mortality. Therefore, the objective was to assess the factors associated with mortality among thoracic trauma patients in Cameroon.
View Article and Find Full Text PDFMitochondrial NAD deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm.
Nat Cardiovasc Res
January 2025
Shanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Thoracic and abdominal aortic aneurysm poses a substantial mortality risk in adults, yet many of its underlying factors remain unidentified. Here, we identify mitochondrial nicotinamide adenine dinucleotide (NAD)⁺ deficiency as a causal factor for the development of aortic aneurysm. Multiomics analysis of 150 surgical aortic specimens indicated impaired NAD salvage and mitochondrial transport in human thoracic aortic aneurysm, with expression of the NAD transporter SLC25A51 inversely correlating with disease severity and postoperative progression.
View Article and Find Full Text PDFMagnetic resonance imaging and pathological findings of aortoiliac thromboembolism with a thoracic aortic mural thrombus in a Japanese Black calf.
J Vet Med Sci
January 2025
Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University.
A 24-day-old female Japanese Black calf presented a sudden paraplegia after a history of watery diarrhea. Antemortem magnetic resonance imaging confirmed the suspicion of thrombotic component in the abdominal aorta, without any spinal cord abnormality at the lumbar region. On necropsy, a massive thrombus occupied the lumen from the distal abdominal aorta to the bifurcation of the external iliac arteries.
View Article and Find Full Text PDFMFGE8 induces anti-PD-1 therapy resistance by promoting extracellular vesicle sorting of PD-L1.
Cell Rep Med
January 2025
Department of Orthopaedics of the Second Affiliated Hospital and Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address:
Anti-PD-1 therapy, effective in patients with various advanced tumors, still encounters the challenge of insensitivity in most patients. Here, we demonstrate that PD-L1 on tumor cell-derived extracellular vesicles (TEVs) is critical for anti-PD-1 therapy resistance. Reducing endogenous and transferring exogenous TEVs abrogates and induces anti-PD-1 therapy resistance, respectively.
View Article and Find Full Text PDFEffect of application of the thoracoabdominal rebalancing (TAR) method in moderate premature children: randomized and controlled clinical trial.
Rev Paul Pediatr
January 2025
Universidade Federal de Alfenas - Alfenas (MG), Brazil.
Objective: To analyze the effect of the thoracoabdominal rebalancing (TAR) method on respiratory biomechanics, respiratory discomfort, pain sensation, and physiological parameters in moderate preterm newborns, compared to a control group.
Methods: This randomized clinical trial was conducted in a neonatal intensive care unit. The evaluation included: Neonatal Infant Pain Scale, physiological parameters, Silverman-Andersen score, and biomechanics (thoracic cirtometry and Charpy angle).
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