The aim of this study is to determine the effect of bolus to the surface dose in oblique electron incidences. Irradiations with 4.5, 6, 7.5, 9, and 12-MeV electron beams were made for the incidence angles of 0 degrees, 15 degrees, 30 degrees, 45 degrees, 60 degrees, 75 degrees and using 3 different bolus setups: (1) unbolused (no bolus), (2) 5-mm bolus, and (3) 10-mm bolus. A set of EBT gafchromic film pieces placed on the phantom surface was irradiated with a 400-cGy dose at D(max) for each setup. Whereas surface dose increased with increasing incidence degrees in the absence of a bolus, it was seen that there was a large surface dose decreasing in the presence of a bolus with increasing incidence angles. For 60 degrees incidence angle, the relative surface doses with unbolused setup were: 88.10%, 90.06%, 89.35%, 90.25%, and 97.10%; with 5-mm bolus: 66.45%, 81.20%, 99.78%, 124.43%, and 116.07%; and with 10-mm bolus: 22.65%, 45.20%, 55.20%, 65.82%, and 90.27% for 4.5, 6, 7.5, 9, and 12 MeV, respectively. The use of bolus in the treatment of highly oblique surfaces with low-energy electron beams significantly decreases the surface dose.
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http://dx.doi.org/10.1016/j.meddos.2008.12.001 | DOI Listing |
J Ethnopharmacol
January 2025
Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, 310014. Electronic address:
Ethnopharmacological Relevance: The Chinese medicine sappanwood is primarily sourced from the dried heartwood of the medicinal plant Caesalpinia sappan Linn., which has been found with a variety of valuable properties including anti-inflammatory, anti-oxidant, and anti-viral effects. Preliminary investigations have demonstrated that sappanwood showed strong anti-SARS-CoV-2 M effects, but the key constituents responsible for SARS-CoV-2 M inhibition and their anti-M mechanisms have not been uncovered.
View Article and Find Full Text PDFJ Radiol Prot
January 2025
Department of Mechanical Engineering, University of Houston, Houston, 77204, UNITED STATES.
Although the Boundary Representation (BREP) method creates detailed surface phantoms of Chinese women of childbearing age, these phantoms cannot be directly used in Monte Carlo simulations. They must first be converted into voxel phantoms, a process that may diminish some of the inherent advantages of the surface phantoms. Therefore, the aim of this study is to construct a tetrahedral mesh (TM) phantom of Chinese women of childbearing age based on the BREP phantom, incorporating micron-level structural refinements to certain organ tissues while maintaining the original model's structure.
View Article and Find Full Text PDFMater Horiz
January 2025
Key Laboratory of Polymer Processing Engineering of the Ministry of Education, National Engineering Research Center of Novel Equipment for Polymer Processing, Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing, South China University of Technology, Guangzhou 510641, People's Republic of China.
Passive daytime radiative cooling offers a promising approach to address energy, environmental, and safety issues caused by global warming. However, the contradiction between high radiative cooling performance and long-lasting ultraviolet (UV) durability is a primary limitation at the current stage. Here, inspired by the ability of epidermal cells and palisade cells on the leaf surface to protect internal leaf structures (such as chloroplasts and nuclei) under drought and high-temperature conditions, a double-layer passive radiative cooling (PRC) porous membrane, which consists of an upper protective layer densely packed with highly ultraviolet-reflective inorganic particles and a bottom cooling layer doped with a variety of optically characterized inorganic particles, was developed to overcome these challenges.
View Article and Find Full Text PDFBiofilm
June 2025
CEB - Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.
Antibiotics are central to managing airway infections in cystic fibrosis (CF), yet current treatments often fail due to the presence of biofilms, settling down the need for seeking therapies targeting biofilms. This study aimed to investigate the antibiofilm activity of aspartic acid and its potential as an adjuvant to tobramycin against biofilms formed by mucoid and small colony variant (SCV) tobramycin tolerant strain. We assessed the effect of aspartic acid on both surface-attached and suspended biofilms within CF artificial mucus and investigated the synergistic impact of combining it with non-lethal tobramycin concentrations.
View Article and Find Full Text PDFJTO Clin Res Rep
February 2025
Department of Medicine, Division of Oncology, Stanford University, Stanford, California.
Introduction: Although tyrosine kinase inhibitors (TKIs) are effective against NSCLC harboring sensitizing gene mutations, acquired resistance is inevitable. Preclinical studies suggest that combining EGFR TKI and monoclonal antibody therapies may have activity in mutated NSCLC that has progressed on TKI therapy alone. Therefore, we prospectively evaluated afatinib plus necitumumab in patients with mutated NSCLC.
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