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Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: part B - behavioral results. | LitMetric

AI Article Synopsis

  • This study explored the effects of oral dimercapto succinic acid (DMSA) on behavioral symptoms in children with autism spectrum disorders (ASD) aged 3-8 years.
  • The research involved two phases: Phase 1 had 65 children receive one round of DMSA, and Phase 2 included 49 children who switched to either DMSA or a placebo for further treatment.
  • Results indicated that both one and seven rounds of DMSA led to significant improvements in various symptoms, suggesting the therapy is safe and potentially beneficial for children with high urinary excretion of toxic metals.

Article Abstract

Background: This study investigated the effects of oral dimercapto succinic acid (DMSA) therapy on the behavioural symptoms of children with autism spectrum disorders (ASD) ages 3-8 years.

Methods: Phase 1 involved 65 children with ASD who received one round of DMSA (3 days). Participants who had high urinary excretion of toxic metals were selected to continue on to phase 2. In phase 2, 49 participants were randomly assigned in a double-blind design to receive an additional 6 rounds of either DMSA or placebo.

Results: The groups receiving one round and seven rounds of DMSA had significant improvements on all the assessment measures. For the seven round group, the degree of improvement on the assessment measures could be partially explained by a regression analysis based on excretion of toxic metals and changes in glutathione (adjusted R2 of 0.28-0.75, p < 0.02 in all cases). One round of DMSA had nearly the same benefit as seven rounds. The assessment measures correlated reasonably with one another at the beginning of the study (r = 0.60-0.87) and even better at the end of the study (r = 0.63-0.94).

Conclusion: Overall, both one and seven rounds of DMSA therapy seems to be reasonably safe in children with ASD who have high urinary excretion of toxic metals, and possibly helpful in reducing some of the symptoms of autism in those children.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770991PMC
http://dx.doi.org/10.1186/1472-6904-9-17DOI Listing

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