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Age-dependent patterns of schizophrenia genetic risk affect cognition.
Schizophr Res
August 2022
Department of Psychology, University of Pittsburgh, United States of America; Department of Psychiatry, University of Pittsburgh, United States of America. Electronic address:
Cognition shares substantial genetic overlap with schizophrenia, yet it remains unclear whether such genetic effects become significant during developmental periods of elevated risk for schizophrenia, such as the peak age of onset. We introduce an investigative framework integrating epidemiological, developmental, and genetic approaches to determine whether genetic effects shared between schizophrenia and cognition are significant across periods of differing risk for schizophrenia onset, and whether these effects are shared with depression. 771 European-American participants, including 636 (ages 15-84 years) from families with at least two first-degree relatives with schizophrenia and 135 unrelated controls, were divided into three age-risk groups based on ages relative to epidemiological age of onset patterns for schizophrenia: Pre-Peak (before peak age-of-onset: 15 to 22 years), Post-Peak (after peak age-of-onset: 23-42 years), and Plateau (during plateau of age-of-onset: over 42 years).
View Article and Find Full Text PDFMental health care utilization in individuals with high levels of psychosis-like experiences: Associations with race and potentially traumatic events.
Cultur Divers Ethnic Minor Psychol
July 2023
Department of Psychology, University of Maryland, Baltimore.
Racial inequities in mental health care utilization (MHCU) are well documented. Marginalized racial groups are more likely to report psychosis-like experiences (PLEs) and are at elevated risk for racial discrimination and trauma, impacting PLE severity. Little is known about how factors associated with race impact treatment seeking among individuals reporting PLEs.
View Article and Find Full Text PDFGenetic influences on externalizing psychopathology overlap with cognitive functioning and show developmental variation.
Eur Psychiatry
March 2021
Department of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Background: Questions remain regarding whether genetic influences on early life psychopathology overlap with cognition and show developmental variation.
Methods: Using data from 9,421 individuals aged 8-21 from the Philadelphia Neurodevelopmental Cohort, factors of psychopathology were generated using a bifactor model of item-level data from a psychiatric interview. Five orthogonal factors were generated: anxious-misery (mood and anxiety), externalizing (attention deficit hyperactivity and conduct disorder), fear (phobias), psychosis-spectrum, and a general factor.
Characteristics of youth with reported family history of psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort.
Schizophr Res
February 2020
Lifespan Brain Institute, Children's Hospital of Philadelphia Department of Child and Adolescent Psychiatry and Behavioral Sciences, Perelman School of Medicine Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Little is known about the impact of family history of psychosis on youth from community samples. To fill this gap, we compared youth with a first-degree relative with psychosis spectrum symptoms (i.e.
View Article and Find Full Text PDFThe contentious debate on evidence-based Global Mental Health care is challenged by the primary mental health program of Jamaica. Political independence in 1962 ushered in the postcolonial Jamaican Government and the deinstitutionalization of the country's only mental hospital along with a plethora of mental health public policy innovations. The training locally of mental health professionals catalyzed institutional change.
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