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All-in-one microfluidic immunosensing device for rapid and end-to-end determination of salivary biomarkers of cardiovascular diseases.
Biosens Bioelectron
December 2024
School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, Zhejiang, 315200, China. Electronic address:
Routine screening for cardiovascular diseases (CVDs) through point-of-care assays for at-home or community-based testing of salivary biomarkers can significantly improve patient outcomes. However, its translatability has been hindered by a dearth of biosensing devices that streamline assay procedures for rapid biomarker quantitation. To address this challenge through end-to-end engineering, we developed an in-house, all-in-one microfluidic immunosensing device that integrates on-chip vibration-enhanced incubation, magnetic-assisted separation using immune magnetic bead probes, and colorimetric readout via absorbance measurements.
View Article and Find Full Text PDFEstablishing an end-to-end workflow for SNSPD fabrication and characterization.
Sci Rep
December 2024
School of Electrical and Electronic Engineering, Nanyang Technological University, 639798, Singapore, Singapore.
The outstanding performance of superconducting nanowire single-photon detectors (SNSPDs) has expanded their application areas from quantum technologies to astronomy, space communication, imaging, and LiDAR. As a result, there has been a surge in demand for these devices, that commercial products cannot readily meet. Consequently, more research and development efforts are being directed towards establishing in-house SNSPD manufacturing, leveraging existing nano-fabrication capabilities that can be customized and fine-tuned for specific needs.
View Article and Find Full Text PDFPoint-of-care additive manufacturing: state of the art and adoption in Spanish hospitals during pre to post COVID-19 era.
3D Print Med
December 2024
Diagnostic Imaging Department, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025, Barcelona, Spain.
Background: 3D technologies [Virtual and Augmented 3D planning, 3D printing (3DP), Additive Manufacturing (AM)] are rapidly being adopted in the healthcare sector, demonstrating their relevance in personalized medicine and the rapid development of medical devices. The study's purpose was to understand the state and evolution of 3DP/AM technologies at the Point-of-Care (PoC), its adoption, organization and process in Spanish hospitals and to understand and compare the evolution of the models, clinical applications, and challenges in utilizing the technology during the COVID-19 pandemic and beyond.
Methods: This was a questionnaire-based qualitative and longitudinal study.
In-House Immunoglobulin Y-Based Immunoassay for Detecting Benzo[a]pyrene in Grilled Pork Samples.
Biosensors (Basel)
December 2024
School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Benzo[a]pyrene (B[a]P) is a hazardous polycyclic aromatic hydrocarbon that accumulates in several environmental matrices as a result of incomplete combustion. Its presence, carcinogenic properties, and tendency for bioaccumulation provide significant risks to human health and the environment. The objective of this study is to create an immunoassay for the detection of benzo[a]pyrene utilizing immunoglobulin Y antibodies.
View Article and Find Full Text PDFDeveloping a novel dosiomics model to predict treatment failures following lung stereotactic body radiation therapy.
Front Oncol
December 2024
Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, United States.
Purpose: The purpose of this study was to investigate the dosiomics features of the interplay between CT density and dose distribution in lung SBRT plans, and to develop a model to predict treatment failure following lung SBRT treatment.
Methods: A retrospective study was conducted involving 179 lung cancer patients treated with SBRT at the University of Nebraska Medical Center (UNMC) between October 2007 and June 2022. Features from the CT image, Biological Effective Dose (BED) and five interaction matrices between CT and BED were extracted using radiomics mathematics.
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