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Acute Cocaine Toxicity Complicated by Cerebral Edema, Respiratory Failure, and Coronary Vasospasm: A Case Report and Review of Multimodal Management Strategies.
Cureus
October 2024
Internal Medicine, Cape Coral Hospital, Cape Coral, USA.
Article Synopsis
- Cocaine use can lead to serious medical issues, including acute and chronic complications that may cause organ failure, and many overdose deaths occur without the drug being laced with other substances like fentanyl.
- A case study of a 40-year-old man shows severe symptoms from suspected cocaine use, including hyperthermia and unresponsiveness, requiring aggressive medical intervention and highlighting complications such as rhabdomyolysis and acute kidney injury.
- Despite initial concerns about heart issues, it was determined that elevated cardiac troponins were related to cocaine-induced effects rather than coronary artery disease, and a previously discovered brain lesion was monitored without needing immediate surgery.
Characteristic Cardiac Magnetic Resonance (CMR) Imaging Findings of Cocaine-Induced Myocardial Injury.
Cureus
August 2024
Cardiology, Baylor Scott & White Medical Center - Temple, Temple, USA.
Article Synopsis
- - Cocaine use can lead to serious heart conditions such as heart attacks and cardiomyopathy, posing significant health risks and burdens on healthcare systems.
- - Cardiac magnetic resonance (CMR) imaging is essential for identifying and assessing heart damage, allowing for the differentiation between acute and chronic injuries linked to cocaine use.
- - Early detection through CMR can help reverse damage caused by cocaine, making it a crucial tool for better management of cocaine-related heart issues.
Cocaine-derived hippuric acid activates mtDNA-STING signaling in alcoholic liver disease: Implications for alcohol and cocaine co-abuse.
Cell Biol Toxicol
August 2024
College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, 28160, South Korea.
Article Synopsis
- The combined use of alcohol and cocaine leads to more significant and unpredictable liver, heart, and brain damage compared to using either substance alone.
- Research involving marmosets and mice demonstrated that using both substances together caused worse liver injury and inflammation than individual use did.
- The study identifies hippuric acid as a critical metabolite linked to increased liver damage through inflammation pathways, suggesting that targeting the HA-STING-TNFR1 signaling axis could be a promising treatment for alcohol- and cocaine-related liver injuries.
Rapid Recovery From Cocaine-Induced Cardiomyopathy: A Case Report.
Cureus
December 2023
Cardiology, Steward Carney Hospital, Dorchester, USA.
Article Synopsis
- - A 33-year-old man experienced shortness of breath and confusion, prompting a medical evaluation.
- - Toxicology tests revealed the presence of cocaine and fentanyl in his system, raising concerns about his heart health.
- - An echocardiogram showed severe heart dysfunction, but his condition significantly improved just four days after the diagnosis of cocaine-induced cardiomyopathy.
Cocaine-Induced Ascending Aortic Thrombus.
Cureus
October 2023
Cardiology, Huntsville Hospital Heart Center, Decatur, USA.
Aortic thrombosis without coexisting atherosclerosis is uncommon. Sometimes, aneurysms or dissections can predispose to thrombus in the abdominal or thoracic aorta. However, ascending aortic thrombus in a non-aneurysmal, non-atherosclerotic aorta is a rare occurrence.
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