We studied the hemodynamic behavior of the pulmonary circulation at rest and during exercise in six patients with MTB. As a group, in contrast to advanced fibrocaseous tuberculosis, these patients exhibited normal pulmonary hemodynamics at rest and during exercise. Only minor abnormalities in pulmonary vascular resistance at exercise (increased PAd-PWP gradient) were noted in two of the patients. The increase in Rp during exercise does not appear to be related to acute hypoxic vasoconstruction but rather to functional changes (compliance or recruitment or both) of the pulmonary microvasculature. In the genesis of these functional changes, chronic alveolar hypoxia and the inflammatory-fibrotic process might be interacting.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1378/chest.99.1.152 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Queen's University, Kingston, ON, Canada; D'OR Institute for Research and Education, Rio de Janeiro, Rio de Janeiro, Brazil.
Background: Physical exercise improves overall brain health, cognition, and stimulates the release of extracellular vesicles (EVs) in humans. Exercise upregulates irisin, a myokine derived from fibronectin type III domain-containing protein 5 (FNDC5) previously shown to mediate the beneficial actions of exercise on memory in mouse models of Alzheimer's disease (AD). Here, we investigated if physical exercise upregulates EVs.
View Article and Find Full Text PDFEfficacy of a hands-free vascular ultrasound probe holder in active and inactive limbs during cycling exercise.
J Appl Physiol (1985)
January 2025
Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Canada.
Measurement of blood flow during exercise is crucial for understanding physiological responses and performance outcomes. However, traditional methods are often invasive, costly, or require substantial training, limiting widespread research in this area. This study introduces the innovative use of limb-affixed ultrasound probe holders for vascular imaging during exercise to overcome these challenges.
View Article and Find Full Text PDFThe role of the circadian timing system in sarcopenia in old age: a scoping review.
Eur Geriatr Med
January 2025
Department of Biomedical and Neuromotor Science, Alma Mater Studiorum Università di Bologna, Ravenna Campus, Ravenna, Italy.
Purpose: Sarcopenia is a progressive and generalized skeletal muscle disorder, involving the accelerated loss of skeletal muscle mass and function, associated with an increased probability of adverse outcomes including falls. The circadian timing system may be involved in molecular pathways leading to sarcopenia in older adults. We aimed to provide an updated and systematic map of the available evidence on the role of the circadian timing system in sarcopenia, specifically related to the aging process.
View Article and Find Full Text PDFIncremental shuttle walking test for calf muscle oxygenation assessment in peripheral arterial disease: a cross-sectional study.
Sci Rep
January 2025
Graduate Program in Rehabilitation Sciences, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627 - Pampulha, Belo Horizonte, CEP 31270-901, MG, Brazil.
People with peripheral arterial disease (PAD) and intermittent claudication (IC) experience impaired walking due to an imbalance between muscle oxygen supply and demand during exercise. Studies with near-infrared spectroscopy (NIRS) during treadmill tests reveal notable tissue deoxygenation with slow recovery. This cross-sectional study aimed to compare behavior of calf muscle oxygenation during the incremental shuttle walking test (ISWT) with a continuous treadmill test (3.
View Article and Find Full Text PDFPhysical activity guidelines for adults with type 2 Diabetes: Systematic review.
Diabetes Res Clin Pract
December 2024
Diabetes Research Centre, College of Life Sciences, Department of Population Health Sciences, University of Leicester, Leicester, UK; NIHR Leicester Biomedical Research Centre, Leicester, UK; Leicester British Heart Foundation Centre of Research Excellence, Leicester, UK.
Aims: The aim of this study was to systematically review recommendations on physical activity for adults with type 2 diabetes (T2D).
Methods: Online databases were searched for clinical practice guidelines (CPG), statements, and recommendations. Two authors screened the guidelines based on eligibility criteria.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!