A review of publications on pesticides assessing the need for 1-year toxicity studies in dogs was performed. Four key peer-reviewed papers with different approaches investigated the value of a 1-year dog study in addition to a 3-month study. Despite different databases and approaches, each concluded with the recommendation to limit the testing of pesticides in dogs to a duration of 3 months. The combined weight of evidence presented in this review reinforces these independent conclusions. Therefore, the routine inclusion of a 1-year dog study as a mandated regulatory requirement for the safety assessment of pesticides is no longer justifiable and a globally harmonized approach should be taken to match the latest legislation of the European Union and the US EPA.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/10408440903300098 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Results From First-in-Human Phase I Study of a Novel CD19-1XX Chimeric Antigen Receptor With Calibrated Signaling in Large B-Cell Lymphoma.
J Clin Oncol
January 2025
Center for Cell Engineering, Sloan Kettering Institute, New York, NY.
Purpose: We designed a CD19-targeted chimeric antigen receptor (CAR) comprising a calibrated signaling module, termed 1XX, that differs from that of conventional CD28/CD3ζ and 4-1BB/CD3ζ CARs. Preclinical data demonstrated that 1XX CARs generated potent effector function without undermining T-cell persistence. We hypothesized that 1XX CAR T cells may be effective at low doses and elicit minimal toxicities.
View Article and Find Full Text PDFGastroenterological Surgery and Management of Infection: A Review.
J Anus Rectum Colon
January 2025
Department of Infectious Diseases, St. Marianna University School of Medicine, Kawasaki, Japan.
Fever and diarrhea are the common symptoms of infection (CDI); however, pseudomembranous enteritis, megacolonization, and paralytic ileus have been observed in severe cases. spores are resistant to several types of disinfectants. Thus, they are often the causative pathogens of healthcare-associated infections.
View Article and Find Full Text PDFHigh-field MRI findings in epileptic dogs with a normal inter-ictal neurological examination.
Front Vet Sci
January 2025
Small Animal Teaching Hospital, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston, United Kingdom.
Introduction: Epilepsy is one of the most common chronic neurological conditions affecting dogs. Previous research exploring the likelihood of a structural cause of epilepsy specifically in dogs with a normal inter-ictal examination is limited to a small population of dogs using low-field MRI. The aims of this study were to establish high-field (1.
View Article and Find Full Text PDFTemozolomide monotherapy versus combination therapies in melanoma: a meta-analysis of efficacy and safety.
Melanoma Res
January 2025
Department of Plastic Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Temozolomide is used in melanoma therapy, but the comparative efficacy and safety of monotherapy vs combination therapies are unclear. This meta-analysis evaluates temozolomide monotherapy vs combination therapies in melanoma patients. PubMed, Embase, and Cochrane Library were searched up to August 2024 for studies comparing temozolomide monotherapy with combination therapies in melanoma.
View Article and Find Full Text PDFPreclinical use of a clinically-relevant scAAV9/SUMF1 vector for the treatment of multiple sulfatase deficiency.
Commun Med (Lond)
January 2025
Rare Disease Translational Center, The Jackson Laboratory, Bar Harbor, ME, USA.
Background: Multiple Sulfatase Deficiency (MSD) is a rare inherited lysosomal storage disorder characterized by loss of function mutations in the SUMF1 gene that manifests as a severe pediatric neurological disease. There are no available targeted therapies for MSD.
Methods: We engineered a viral vector (AAV9/SUMF1) to deliver working copies of the SUMF1 gene and tested the vector in Sumf1 knock out mice that generally display a median lifespan of 10 days.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!