Vet Anaesth Analg
Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Korea.
Published: November 2009
Objective: To investigate the effects of atipamezole administered before butorphanol, on tail-flick latency (TFL) and also following medetomidine-ketamine anaesthesia in rats.
Study Design: Prospective, randomized experimental study.
Animals: Thirty-four adult male Sprague-Dawley rats weighing 260-390 g.
Methods: TFL in 50 degrees C water was used to measure antinociception. In the first experiment, rats received saline (n = 5) or atipamezole (n = 5) followed by butorphanol treatments. In the second experiment, three groups of rats received saline (n = 8), atipamezole (n = 8) or atimpamezole (n = 8) followed by butorphanol 60 minutes after medetomidine-ketamine administration.
Results: In the first experiment, butorphanol significantly increased TFL compared to baseline. Atipamezole significantly decreased this effect. In the second experiment, TFL was significantly increased after recovery from medetomidine-ketamine anaesthesia compared to baseline. This was almost completely blocked by atipamezole. Atipamezole with butorphanol after recovery from the anaesthesia significantly reduced TFL compared to saline but still significantly increased TFL compared to the baseline.
Conclusion And Clinical Relevance: Atipamezole attenuated the analgesic effects of butorphanol. When postoperative atipamezole is used to hasten recovery from anaesthesia in rats, it may interfere with the postoperative analgesic effect of butorphanol.
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http://dx.doi.org/10.1111/j.1467-2995.2009.00497.x | DOI Listing |
Vet Res Forum
May 2024
Department of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
Various companion birds, including budgerigars, are anesthetized with injectable anesthesia. The current study aimed to evaluate oxidative stress indices including malondialdehyde (MDA), total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) along with clinical parameters such as the time required to induce, maintain and recover from medetomidine-ketamine anesthesia and midazolam-ketamine anesthesia in budgerigars. Among 20 mature and healthy budgerigars, three groups were assigned as follows: Control (n = 4) to determine baseline oxidative stress indices medetomidine + ketamine (n = 8) anesthetized by intramuscular injections of medetomidine (0.
View Article and Find Full Text PDFJ Zoo Wildl Med
January 2024
Ghent University, Faculty of Veterinary Medicine, Department of Large Animal Surgery, Anaesthesia and Orthopaedics, Salisburylaan 9820 Belgium.
One male and one female giant panda () from a Belgian zoo were anesthetized on eight different occasions over a course of 4 yr for electro-ejaculation ( = 3) or artificial insemination ( = 5). Medetomidine (0.03-0.
View Article and Find Full Text PDFPurpose: This study evaluated the DNA damage caused by repeated doses of xylazine-ketamine and medetomidine-ketamine anesthesia in the liver and kidneys.
Methods: In this study, 60 rats were used. The rats were divided into group 1 (xylazine-ketamine), and group 2 (medetomidine-ketamine), and these anesthetic combinations were administered to the rats at repeated doses with 30-min intervals.
Lab Anim
December 2023
Department of Veterinary and Animal Sciences, University of Copenhagen, Denmark.
Pigs are widely used in metabolic research with procedures often requiring general anaesthesia. The aim was to investigate the effect of four different anaesthetic protocols: 1) isoflurane inhalation, 2) propofol infusion, 3) a mixture of tiletamine, zolazepam, medetomidine, ketamine and butorphanol (TZMKB)) and 4) ketamine combined with midazolam and xylazine (KMX)) on selected biomarkers during basal and glucose stimulated conditions. Eight domestic pigs were included in a cross-over design.
View Article and Find Full Text PDFVet Anaesth Analg
September 2023
Parc Zoologique & Botanique de Mulhouse, Mulhouse, France.
Objective: To compare the effect of two anaesthetic protocols on heart rate (HR), time to muscle relaxation and tracheal intubation and time to surgical plane of anaesthesia, in Trachemys scripta spp. undergoing oophorectomy.
Study Design: Prospective randomized clinical study.
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